Skip to main content
Log in

Biological indicators of cadmium exposure and toxicity

  • Reviews
  • Cadmium —a complex environmental problem
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The increasing environmental and occupational exposure of populations to cadmium creates the need for biological indicators of cadmium exposure and toxicity. The advantages and disadvantages of monitoring blood cadmium, urinary, fecal, hair, and tissue cadmium, serum creatinine, β2-microglobulin, α1-antitrypsin and other proteins, and urinary amino acids, enzymes, total proteins, glucose β2-microglobulin, retinol-binding protein, lysozyme, and metallothionein are discussed. It is concluded that urinary cadmium, metallothionein and β2-microglobulin may be used together to assess cadmium, exposure and toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Adams, R., β2-Microglobulin levels in nickel-cadmium battery workers, in: Occupational Exposure to Cadmium, Report on Seminar, London, 20 March 1980, pp. 41–42. Cadmium Association. London 1980.

    Google Scholar 

  2. Axelsson, B., and Piscator, M., Renal damage after prolonged exposure to cadmium. Archs envir. Hlth12 (1966) 360–373.

    Article  CAS  Google Scholar 

  3. Baker, E.L., Peterson, W.A., Holtz, J.L., Coleman, C., and Landrigon, P.J., Subacture cadmium intoxication in jewelry workers: an evaluation of diagnostic procedures. Archs envir. Hlth20 (1979) 173–177.

    Article  Google Scholar 

  4. Bernard, A., Buchet, J.P., Roels, H., Masson, P., and Lauwerys, R., Renal excretion of proteins and enzymes in workers exposed to cadmium. Eur. J. clin. Invest.9 (1979) 11–22.

    Article  CAS  PubMed  Google Scholar 

  5. Bernard, A., Goret, A., Buchet, J.P., Roels, H., and Lauwerys, R., Significance of cadmium levels in blood and urine during long-term exposure of rats to cadmium. J. Toxic. envir. Hlth6 (1980) 175–184.

    Article  CAS  Google Scholar 

  6. Bernard, A., Goret, A., Roels, H., Buchet, J.P., and Lauwerys, R., Experimental confirmation in rats of the mixed type proteinuria observed in workers exposed to cadmium. Toxicology10 (1978) 369–375.

    Article  CAS  PubMed  Google Scholar 

  7. Bernard, A., Roels, H., Buchet, J.P., Masson, P.L., and Lauwerys, R., α1-Antitrypsin levels in workers exposed to cadmium. In: Clinical Chemistry and Chemical Toxicology of Metals, pp. 161–164. Ed. S.S. Brown. Elsevier/North Holland Biomedical Press, Amsterdam 1977.

    Google Scholar 

  8. Bonner, F.W., King, L.J., and Parke, D.V., The tissue disposition and urinary excretion of cadmium, zinc,copper, and iron following repeated parenteral administration of cadmium to rats. Chem. biol. Interact.27 (1979) 343–351.

    Article  CAS  PubMed  Google Scholar 

  9. Bonner, F.W., King, L.J., and Parke, D.V., The urinary excretion of alkaline phosphatase after the repeated parenteral administration of cadmium to rats given a high dietary supplement of zinc. Toxic. Lett.6 (1980) 369–372.

    Article  CAS  Google Scholar 

  10. Brancato, D.J., Picchioni, A.L., and Chin, L.J., Cadmium levels in hair and other tissues during continuous cadmium intake. J. Toxic. envir. Hlth2 (1976) 351–359.

    Article  CAS  Google Scholar 

  11. Chang, C.C., Lauwerys, R., Bernard, A., Roels, H., Buchet, J.P., and Garvey, J.S., Metallothionein in cadmium-exposed workers. Envir. Res.23 (1980) 422–428.

    Article  CAS  Google Scholar 

  12. Chowdhury, P., and Louria, D.B., Influence of cadmium and other trace metals on human α1-antitrypsin: anin vitro study. Science191 (1976) 480–481.

    Article  CAS  PubMed  Google Scholar 

  13. Durnam, D., and Palmiter, R.J., Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J. biol. Chem.256 (1981) 5712–5716.

    Article  CAS  PubMed  Google Scholar 

  14. Elinder, C.G., Kjellström, T., Lind, B., Molander, M.L., and Silander, T., Cadmium concentration in human liver, blood, and bile: comparison with a metabolic model. Envir. Res.17 (1978) 236–241.

    Article  CAS  Google Scholar 

  15. Ellis, K.J., Morgan, W.D., Zanzi, I., Yasumura, S., Vartsky, D., and Cohn, S.H., Critical concentration of cadmium in human renal cortex: dose-effect studies in cadmium smelter workers. J. Toxic. envir. Hlth7 (1981) 691–703.

    Article  CAS  Google Scholar 

  16. Ellis, K.J., Yasumura, S., and Cohn, S.H., Hair cadmium content: is it a biological indicator of the body burden of cadmium for the occupationally exposed worker? Am. J. ind. Med.2 (1981) 323–330.

    Article  CAS  PubMed  Google Scholar 

  17. Friberg, L., Piscator, M., Nordberg, G., and Kjellström, T., Cadmium in the Environment, 2nd edn, pp. 23–91. CRC Press, Cleveland, Ohio, 1974.

    Google Scholar 

  18. Goyer, R.A., Tsuchiya, K., Leonard, D.L., and Kahyo, H., Aminoaciduria in Japanese workers in the lead and cadmium industries. Am. J. clin. Path.57 (1972) 635–642.

    Article  CAS  PubMed  Google Scholar 

  19. Jacobson, K.B., and Turner, J.E., The interaction of cadmium and other metal ions with proteins and nucleic acids. Toxicology16 (1980) 1–37.

    Article  CAS  PubMed  Google Scholar 

  20. Jeandot, R., and Doisneau, R., Epidemiologic study of β2-microglobulin in cadmium-exposed workers in a nickel-cadmium battery plant, in: Occupational Exposure to Cadmium, Report on Seminar, London, 20 March 1980, pp. 37–41. Cadmium Association, London 1980.

    Google Scholar 

  21. Kazantzis, G., Significance of β2-microglobulin as a measure of cadmium exposure, in: Occupational Exposure to Cadmium, Report on Seminar. London, 20 March 1980, pp. 55–56. Cadmium Association, London 1980.

    Google Scholar 

  22. Kjellström, T., Evrin, P.-E., and Rahnster, B., Dose-response analysis of cadmium-induced tubular proteinuria: a study of urinary β2-microglobulin excretion among workers in a battery factory. Envir. Res.13 (1977) 303–317.

    Article  Google Scholar 

  23. Kjellström, T., and Piscator, M., Phadedoc Diagnostic Communications, No. 1, pp. 4–20. Pharmacia Diagnostics, Uppsala, Sweden 1977.

    Google Scholar 

  24. Kjellström, T., Shiroishi, K., and Evrin, P.-E., Urinary β2-microglobulin excretion among people exposed to cadmium in the general environment: an epidemiological study in cooperation between Japan and Sweden. Envir. Res.13 (1977) 318–344.

    Article  Google Scholar 

  25. Kojima, S., Haga, Y., Kurihara, T., Yamawaki, T., and Kjellström, T., A comparison between fecal cadmium and urinary β2-microglobulin, total protein, and cadmium among Japanese farmers. An epidemiological study of cooperation between Japan and Sweden. Envir. Res.14 (1977) 436–451.

    Article  CAS  Google Scholar 

  26. Lauwerys, R.R., Buchet, J.P., and Roels, H., The relationship between cadmium exposure or body burden and the concentration of cadmium in blood and urine in man. Int. Archs occup. envir. Hlth36 (1976) 375–385.

    Google Scholar 

  27. Lauwerys, R.R., Buchet, J.P., Roels, H.A., Brouwers, J., and Stanescu, D., Epidemiological survey of workers exposed to cadmium, Archs envir. Hlth28 (1974) 145–148.

    Article  CAS  Google Scholar 

  28. Lauwerys, R.R., Roels, H., Regniers, M., Buchet, J.P., Bernard, A., and Goret, A., Significance of cadmium concentration in blood and urine in workers exposed to cadmium. Envir. Res.20 (1979) 375–391.

    Article  CAS  Google Scholar 

  29. Nishiyama, K., and Nordberg, G.F., Adsorption and elution of cadmium on hair. Archs envir. Hlth25 (1972) 92–96.

    Article  CAS  Google Scholar 

  30. Nogawa, K., Ishizaki, A., and Kobayashi, E., A comparison between health effects of cadmium and cadmium concentration in urine among inhabitants of the Itai-Itai disease endemic district. Envir. Res.18 (1979) 397–409.

    Article  CAS  Google Scholar 

  31. Nogawa, K., Ishizaki, A., and Kawano, S., Statistical observation of the dose-response relationships of cadmium based on epidemiological studies in the Kakehaski River Basin. Envir. Res.15 (1978) 185–198.

    Article  CAS  Google Scholar 

  32. Nogawa, K., Kobayashi, E., Inaoka, H., and Ishizaki, A., The relationship between the renal effects of cadmium and cadmium concentrations in urine among the inhabitants of cadmium-polluted areas. Envir. Res.14 (1977) 391–400.

    Article  CAS  Google Scholar 

  33. Nogawa, K., Kobayashi, E., and Ishizaki, A., Clinico-chemical studies on chronic cadmium poisoning (Part II). Results of blood examinations. Jap. J. Hyg.34 (1979) 415–419.

    Article  CAS  PubMed  Google Scholar 

  34. Nomiyama, K., Does a critical concentration of cadmium in human renal cortex exist? J. Toxic. envir. Hlth3 (1977) 607–609.

    Article  CAS  Google Scholar 

  35. Nomiyama, K., Toxicity of cadmium-mechanism and diagnosis, in: Progress in Water Technology, vol. 7, pp. 15–23. Ed. P.A. Krenket. Pergamon Press, Oxford, 1975.

    Google Scholar 

  36. Nomiyama, K., Experimental studies on animals: in vivo experiments, in: Cadmium Studies in Japan, a review, pp. 47–86. Ed. K. Tsuchiya. Elsevier/North Holland Biomedical Press, New York and Kodansha, Tokyo 1978.

    Google Scholar 

  37. Nomiyama, K., and Nomiyama, H., Mechanism of urinary excretion of cadmium: experimental studies in rabbits, in: Effects and Dose-Response Relationships of Toxic Metals, pp. 371–379. Ed. G.F. Nordberg, Elsevier Scientific Publishing Company, Amserdam 1976.

    Google Scholar 

  38. Nomiyama, K., Nomiyama, H., Akahori, F., and Masaoki, T., Further studies on effects of dietary cadmium on rhesus monkeys. (5) Renal effects, in: Recent Studies in Health Effects of Cadmium in Japan, pp. 59–104. Environment Agency, Office of Health Studies 1981.

  39. Nomiyama, K., Nomiyama, H., Nomura, Y., Taguchi, T., Matsui, K., Yotoriyama, M., Akahori, F., Iwao, S., Koizumi, N., Masaoka, T., Kitamura, S., Tsuchiya, K., Suzuki, T., and Kobayashi, K., Effect of dietary cadmium on rhesus monkeys. Envir. Hlth Perspect.28 (1979) 223–243.

    Article  CAS  Google Scholar 

  40. Nomiyama, K., Sugata, Y., Murata, I., and Nakagawa, S., Urinary low molecular weight proteins in Itai-Itai disease. Envir. Res.6 (1974) 373–81.

    Article  Google Scholar 

  41. Nomiyama, K., Sugata, Y., Yamamoto, A., and Nomiyama, H., Effects of dietary cadmium on rabbits. I. Early signs of cadmium intoxication. Toxic. appl. Pharmac.31 (1975) 4–12.

    Article  CAS  Google Scholar 

  42. Nordberg, G.F., Cadmium metabolism and toxicity. Experimental studies on mice with special reference to the use of biological materials as indices of retention and the possible role of metallothionein in transport and detoxification of cadmium. Envir. Physiol. Biochem.2 (1972) 7–36.

    CAS  Google Scholar 

  43. Nordberg, G.F., Garvey, J.S., and Chang, C.C., Metallothionein in plasma and urine of cadmium workers. Envir. Res.28 (1982) 170–182.

    Article  Google Scholar 

  44. Nordberg, G.F., and Nishiyama, K., Whole body and hair retention of cadmium in mice. Archs envir. Hlth24 (1972) 209–214.

    Article  CAS  Google Scholar 

  45. Nordberg, G.F., and Piscator, M., Influence of long term cadmium exposure on urinary excretion of protein and cadmium in mice. Envir. Physiol. Biochem.2 (1972) 37–49.

    CAS  Google Scholar 

  46. Piscator, M., Proteinuria in chronic cadmium poisoning. I. An electrophoretic and chemical study of urinary and serum proteins from workers with chronic cadmium poisoning. Archs envir. Hlth4 (1962) 607–621.

    Article  CAS  Google Scholar 

  47. Piscator, M., Proteinuria and chronic cadmium poisoning. III. Electrophoretic and immunoelectrophoretic studies on urinary proteins from cadmium workers, with special reference to the excretion of low molecular weight proteins. Archs envir. Hlth12 (1966) 335–344.

    Article  CAS  Google Scholar 

  48. Piscator, M., Serum β2-microglobulin in cadmium exposed workers. Path. Biol.26 (1978) 321–323.

    CAS  Google Scholar 

  49. Piscator, M., and Axelsson, B., Serum proteins and kidney function after exposure to cadmium. Archs envir. Hlth21 (1970) 604–608.

    Article  CAS  Google Scholar 

  50. Price, R.G., Urinary enzymes, nephrotoxicity, and renal disease. Toxicology23 (1982) 99–134.

    Article  CAS  PubMed  Google Scholar 

  51. Roels, H., Bernard, A., Buchet, J.P., Lauwerys, R., and Masson, P., Urinary excretion of β2-microglobulin and other proteins in workers exposed to cadmium, lead or mercury. Path. Biol.26 (1978) 329–331.

    CAS  Google Scholar 

  52. Roels, H., Lauwerys, R.R., Buchet, J.P., Bernard, A., Chettle, D.R., Harvey, T.C., and Al-Haddad, I.K., In vivo measurement of liver and kidney cadmium in workers exposed to this metal: its significance with respect to cadmium in blood and urine. Envir. Res.26 (1981) 217–240.

    Article  CAS  Google Scholar 

  53. Roels, H., Lauwerys, R., Materne, D., and Buchet, J.P., Study on cadmium proteinuria. Glomerular dysfunction: an early sign of renal impairment. Proceedings, Recent Advances in the Assessment of the Health Effects of Environmental Pollution2 (1974) 631–641.

    Google Scholar 

  54. Sakurai, H., Occupational exposure, in: Cadmium Studies in Japan, a review, pp. 133–144. Ed. K. Tsuchiya. Elsevier/North Holland Biomedical Press, New York and Kodansha, Tokyo 1978.

    Google Scholar 

  55. Schaller, K.H., Gonzales, J., Thurauf, J., and Schiele, R., Früherkennung von Nierenschäden bei beruflich gegenüber Blei, Quecksilber und Cadmium exponierten Personen. Zbl. Bakt. Hyg.171 (1980) 320–335.

    CAS  Google Scholar 

  56. Shaikh, Z.A., and Smith, J.C., Metabolism of orally ingested cadmium in humans, in: Mechanisms of Toxicity and Hazard Evaluation, pp. 569–574. Eds B. Holmstedt, R. Lauwerys, M. Mercier and M. Roberfroid. Elsevier/North Holland Biomedical Press, Amsterdam 1980.

    Google Scholar 

  57. Shaikh, Z.A., and Tohyama, C., Urinary metallothionein: a specific test for monitoring occupational cadmium exposure. Vet. hum. Toxic.24 (1982) 276.

    Google Scholar 

  58. Shigematsu, I., and Kawaguchi, T., Environmental pollution and health effects: Akita Prefecture, in: Cadmium Studies in Japan, a Review, pp. 192–199. Ed. K. Tsuchiya. Elsevier/North Holland Biomedical Press, New York and Kodansha, Tokyo 1978.

    Google Scholar 

  59. Shiroishi, K., Kjellström, T., Kubota, K., Evrin, P.-E., Anayama, M., Vesterberg, O., Shinada, T., Piscator, M., Iwate, T., and Nishino, H., Urine analysis for detection of cadmium-induced renal changes with special reference to β2-microglobulin. Envir. Res.13 (1977) 407–424.

    Article  CAS  Google Scholar 

  60. Taniguchi, N., Tanaka, M., Kishihara, C., Ohno, H., Kondo, T., Matsuda, I., Fujino, T., and Harada, M., Determination of carbonic anhydrase C and β2-microglobulin by radioimmunoassay in urine of heavy-metal-exposed subjects and patients with renal tubular acidosis. Envir. Res.20 (1979) 154–161.

    Article  CAS  Google Scholar 

  61. Tohyma, C., and Shaikh, Z.A., Metallothionein in plasma and urine of cadmium-exposed rats determined by a single antibody radioimmunoassay. Fundam. appl. Toxic.1 (1981) 1–7.

    Google Scholar 

  62. Tohya, C., Shaikh, Z.A., Ellis, K.J., and Cohn, S.H., Metallothionein excretion in urine upon cadmium exposure: its relationship with liver and kidney cadmium. Toxicology22 (1981) 181–191.

    Article  Google Scholar 

  63. Tohyama, C., Shaikh, Z.A., Nogawa, K., Kobayashi, E., and Honda, R., Elevated urinary excretion of metallothionein due to environmental cadmium exposure. Toxicology20 (1981)289–297.

    Article  CAS  PubMed  Google Scholar 

  64. Tohyama, C., Shaikh, Z.A., Nogawa, K., Kobayashi, E., and Honda, R., Urinary metallothionein as a new index of renal dysfunction in «Itai-Itai» disease patients and other Japanese women environmentally exposed to cadmium. Arch. Toxic.50 (1982) 159–166.

    Article  CAS  Google Scholar 

  65. Tsuchiya, K., Cadmium in human urine, feces, blood, hair,organs and tissues, in: Cadmium Studies in Japan, a Review, pp. 37–43. Ed. K. Tsuchiya. Elsevier/North Holland Biomedical Press, New York and Kodansha, Tokyo 1978.

    Google Scholar 

  66. Tsuchiya, K., Iwao, S., Sugita, M., and Sakurai, H., Increased urinary B2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of B2-microglobulin. Envir. Hlth Perspect.28 (1979) 147–153.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shaikh, Z.A., Smith, L.M. Biological indicators of cadmium exposure and toxicity. Experientia 40, 36–43 (1984). https://doi.org/10.1007/BF01959100

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01959100

Keywords

Navigation