Summary
The effects of externally and internally applied bradykinin on the excitability of single myelinated nerve fibers were studied. External bradykinin (10 μM) slightly prolongs the action potential of a single myelinated nerve fiber; hence, when the fibers are stimulated by long-lasting pulses, this raises the frequency of repetitive firing in sensory fibers and evokes repetitive activity in motor fibers. Under voltage-clamp conditions, sodium channel inactivation is slowed, while sodium channel activation remains unaffected. Prolonged depolarization of th membrane leads to a maintained sodium current. The voltage dependence of the steady-state sodium current inactivation (h ∞) is shifted in the depolarized direction by ∼ 10 mV. Internally applied bradykinin produces a frequency-dependent block of the sodium current. The phenomena described here imply that more than one site on the sodium channel is modified by bradykinin.
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Bergman, C., Dubois, J. M., Rojas, E., and Rathmayer, W., Biochim. biophys. Acta455 (1976) 173.
Catterall, W. A., A. Rev. Pharmac. Tox.20 (1980) 15.
Neumcke, B., Schwarz, W., and Stämpfli, R., Biochim. biophys. Acta814 (1985) 111.
Beck, P. W., and Handwerker, H. O., Pflügers Arch.347 (1974) 209.
Lewis, G. P., and Reit, E., J. Physiol.179 (1965) 538.
Juan, H., and Lembeck, F., Archs Pharmac.283 (1974) 151.
Szolcsanyi, J., J. Physiol.338 (1987) 9.
Campese, V. M., and Mitolo-Chieppa, D., in: Vasopeptides. Chemistry, Pharmacology and Pathophysiology, p. 477. Eds N. Back and F. Sicuteri. Plenum Publishing Corp., New York 1971.
Nonner, W., Pflügers Arch.309 (1969) 176.
Dubois, J. M., and Bergman, C., Pflügers Arch.370 (1977) 185.
Chiu, S. Y., J. Physiol.273 (1977) 573.
Dubois, J. M., and Bergman, C., Pflügers Arch.357 (1975) 145.
Meves, H., Prog. Biophys. molec. Biol.33 (1978) 207.
Frankenhauser, B., and Hodgkin, A. L., J. Physiol.137 (1957) 218.
Hille, B., J. gen. Physiol.51 (1968) 221.
Carratù, M. R., Dubois, J. M., and Mitolo-Chieppa, D., Neuropharmacology21 (1982) 619.
Khodorov, B., Shishkova, L., Peganov, E., and Revenko, S., Biochim. biophys. Acta433 (1976) 409.
Strichartz, G. R., J. gen. Physiol.62 (1973) 37.
Rojas, E., and Rudy, B., J. Physiol.262 (1976) 501.
Eaton, D. C., Brodwick, M. S., Oxford, G. S., and Rudy, B., Nature271 (1978) 473.
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Carratù, M.R., Mitolo-Chieppa, D. Interaction between bradykinin and voltage-sensitive sodium channels in myelinated nerve fibers. Experientia 45, 346–349 (1989). https://doi.org/10.1007/BF01957473
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DOI: https://doi.org/10.1007/BF01957473