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Successful treatment of recurrent thrombotic thrombocytopenic purpura with plasmapheresis and vincristine

  • Nephrology/Urology
  • Original Paper
  • Published:
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Abstract

An adolescent girl with severe thrombotic thrombocytopenic purpura (TTP) remained in a critical condition after 3, weeks of combined treatment with antiplatelet drugs, plasma infusions and plasma exchange. The introduction of vincristine resulted in gradual improvement and eventual complete remission which lasted for 2 years. When she relapsed, immediate improvement was observed with the combined treatment of plasmapheresis and vincristine. She has now been in complete remission again for 10 months. It is suggested that plasmapheresis plus vincristine should be used as the initial treatment for children with TTP.

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Abbreviations

HUS :

haemolyticuraemic syndrome

TTP :

thrombotic thrombocytopenic purpura

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Authors and Affiliations

  1. Department of Paediatrics, University Hospital, Gasthuisberg, Herestraat 49, B-3000, leuven, Belgium

    S. Van Gool, P. Brock, P. Van Laer, R. Van Damme-lombaerts, W. Proesmans & M. Casteels-Van Daele

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  1. S. Van Gool
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  2. P. Brock
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  3. P. Van Laer
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  4. R. Van Damme-lombaerts
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  5. W. Proesmans
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  6. M. Casteels-Van Daele
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Van Gool, S., Brock, P., Van Laer, P. et al. Successful treatment of recurrent thrombotic thrombocytopenic purpura with plasmapheresis and vincristine. Eur J Pediatr 153, 517–519 (1994). https://doi.org/10.1007/BF01957008

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  • DOI: https://doi.org/10.1007/BF01957008

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