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Effects of cadmium on the immune system of mice

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Summary

Chronic oral exposure of mice to Cd++ inhibits cell-mediated immunity of delayed type hypersensitivity induced by sheep red blood cells (SRBC). No effect was detected on humoral immune response to SRBC. Spleen cells derived from mice exposed to Cd++ showed in vitro enhanced response to T and B cell mitogens. These results demonstrate that Cd++ exposure alters the immune system of mice.

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Author notes

  1. Ch. Krause

    Present address: Institut für Wasser, Boden- und Lufthygiene, Corrensplatz, D-1000, Berlin 33, Germany

  2. G. Jautzke & U. Gross

    Present address: Institut für Pathologie, Klinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Germany

  3. T. Diamantstein

    Present address: Immunologische Forschungseinheit, Klinikum Steglitz, Freie Universität Berlin, Berlin, Germany

Authors and Affiliations

  1. Robert Koch-Institut, Nordufer 20, D-1000, Berlin 65, Germany

    S. Müller, K. -E. Gillert, Ch. Krause, G. Jautzke, U. Gross & T. Diamantstein

Authors
  1. S. Müller
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  2. K. -E. Gillert
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  3. Ch. Krause
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  4. G. Jautzke
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  5. U. Gross
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  6. T. Diamantstein
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Additional information

Dedicated to Prof. Georg Henneberg on the occasion of his 70th anniversary on 12.10.1978.

Acknowledgments. Supported by a grant from the Umweltbundesamt. We thank Ms Odenwald, Ms Schulz, Klinikum Steglitz, and Ms Emeis, Robert Koch-Institut Abt. Immunologie, for the excellent technical assistance.

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Müller, S., Gillert, K.E., Krause, C. et al. Effects of cadmium on the immune system of mice. Experientia 35, 909–910 (1979). https://doi.org/10.1007/BF01955143

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  • DOI: https://doi.org/10.1007/BF01955143

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