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Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II

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Summary

[1-N4-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertensin (Ciba). Rabbit aorta strips gave intrinsic activity αE=1, a PD2 of 6.92±0.09 and an affinity relative to [Asn1]-angiotensin II of 6.5%.

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Author notes

  1. P. Cordopatis (Visiting fellow)

    Present address: Laboratory of Organic Chemistry, University of Patras, Patras, Greece

Authors and Affiliations

  1. Laboratory of Biological Chemistry, University of Mons, Mons, Belgium

    P. Cordopatis (Visiting fellow), J. Brison, J. Dirkx & D. Theodoropoulos

  2. Laboratory of Organic Chemistry, University of Patras, Patras, Greece

    J. Brison, J. Dirkx & D. Theodoropoulos

Authors
  1. P. Cordopatis
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  2. J. Brison
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  3. J. Dirkx
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  4. D. Theodoropoulos
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Additional information

The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. — Per le brevi comunicazioni è responsabile solo l'autore. — Ответственность за короткие сообщения несёт исключительно автор. — Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves.

Acknowledgment. The authors wish to express their appreciation to Dr Emanuel Escher, School of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Quebec, for his help in providing the biological data and critical comments.

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Cordopatis, P., Brison, J., Dirkx, J. et al. Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II. Experientia 35, 849–850 (1979). https://doi.org/10.1007/BF01955103

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  • DOI: https://doi.org/10.1007/BF01955103

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