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The effect of guanethidine treatment of testicular blood flow and testosterone production in rats

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Summary

Testicular blood flow was measured bymeans of Xenon-133 clearance in control rats and rats treated with guanethidine for 3 weeks. Plasma and testis testosterone concentrations were also measured, and the effect of hCG-treatment was examined. No difference in testicular blood flow between the control group and the guanethidinetreated group was found. However, in guanethidine-treated rats, plasma and testis testosterone concentrations after hCG-treatment were significantly decreased. The results may indicate that adrenergic nerves are involved in the regulation of Leydig cell function.

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Authors and Affiliations

  1. Department of Urology and Andrology, University of Umeå, S-901 87, Umeå, Sweden

    J. E. Damber

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  1. J. E. Damber
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Damber, J.E. The effect of guanethidine treatment of testicular blood flow and testosterone production in rats. Experientia 46, 486–487 (1990). https://doi.org/10.1007/BF01954240

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  • DOI: https://doi.org/10.1007/BF01954240

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