Abstract
The spontaneous variation in plasma testosterone was studied in 4 dogs in a 24 h period. Blood samples were taken with 1½ h interval. A variation of 26–62 % was found in the plasma testosterone concentration and the values ranged from 2.7–15.6; 0.7–10.4; 4.2–17.3; 8.7–23 nmol/l. No effect of intramuscular injection of 150 i.u. HCG could be seen on the plasma testosterone levels in samples taken 5, 10, 20 or 30 min post injection. Thereafter plasma testosterone levels increased to reach levels equal to peak concentration in the control period 1½ h post injection. The variation in the plasma testosterone concentration 1½, 3 and 4½ h post HCG injection was reduced to 8.95 ± 2.8 % (mean ± s). Plasma testosterone in a sample taken 3 h after HCG injection might thus be indicative of a Leydig cell dysfunction in the dog. An additional increase (P < 0.001) in plasma testosterone levels was observed 21–30 h post injection. Thereafter levels of testosterone fell to pre-stimulation values.
Sammendrag
Variasjonen i plasma testosteron ble studert hos 4 voksne hannhumder i en 24 timers periode. Blodprøver ble tatt med 1½ times mellomrom. Plasma testosteron konsentrasjonen svingte mellom 2,7– 16,6; 0,7–10,4; 4,2–17,3; 8,7–23 nmol/1. Verdiene viste en varians mellom 26–62 %. Ingen effekt av intramuskulær injeksjon av 150 i.u. HCG kunne påvises i blodprøver tatt 5, 10, 20 eller 30 min etter injeksjonen. Deretter steg nivået av testosteron i plasma og nådde 1½ time etter HCG injeksjonen et nivå likt toppkonsentrasjonen i kontrollperioden. Variansen i plasma testosteron konsentrasjonen 1½, 3 og 4½ time etter time etter HCG injeksjonen var redusert til 8,95 ± 2,8 % (gjennomsnitt ± s). Plasma testosteron i en prøve 3 timer etter HCG injeksjon vil kunne indikere en dysfunksjon i Leydigcellene hos hund. En ytterligere øking (P < 0,001) i plasma testosteron nivå ble observert 21–30 timer etter injeksjonen. Deretter falt testosteron nivået til verdier målt i kontrollperioden.
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The investigation was financially supported by the Agricultural Research Council of Norway
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Sundby, A., Ulstein, T. Plasma Concentrations of Testosterone in the Male Dog and Plasma Testosterone Profile Following Single Intramuscular Injection of HCG. Acta Vet Scand 22, 409–416 (1981). https://doi.org/10.1186/BF03548666
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DOI: https://doi.org/10.1186/BF03548666