Summary
The effects of endotoxin on mouse liver phospholipid fatty acid composition have been investigated. Administration of endotoxin fromSalmonella abortus equi led to a decrease in the polyunsaturated fatty acid content of livers from mice sensitized with Bacille Calmette Guérin (GCG). The content of arachidonic acid fell significantly in both the phosphatidylcholine and phosphatidylinositol fractions whereas in the phosphatidylethanolamine fraction the linoleic acid content was significantly reduced. The polyunsaturated fatty acids were replaced by increased amounts of oleic acid and palmitic acid, leading to a reduction in the polyunsaturated to saturated fatty acid ratio.
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References
Suter, E., and Kirsanow, E. M., Immunology4 (1961) 354.
Jackson, S. K., Stark, J. M., Taylor, S., and Harwood, J. L., Br. J. exp. Path.70 (1989) 435.
Mackaness, G. B., in: Infectious Agents and Host Reactions, p. 62. Eds N. Mudds and W. B. Sanders. Philadephia 1972.
Adams, D. O., Fedn Proc.41 (1982) 2193.
Fletcher, J. R., Scand J. inf. Dis. suppl.31 (1982) 55.
Ogletree, M. L., Oates, J. A., Brigham, K. A., and Hubbard, W. C., Prostaglandins23 (1982) 459.
Garbus, J., De Luca, H. F., Loomans, M. E., and Strong, F. M., J. biol. Chem.238 (1963) 59.
Bergelson, L. D., Dyatlovitskaya, E. V., Torkhovskaya, T. I., Sorokina, I. B., and Gorkova, N.P., Biochim. biophys. Acta210 (1970) 287.
Cuatrecasas, P., and Greaves, M. F. (eds) Receptors and Recognition, series A, vol. 1, pp. 61–117. Chapman and Hall, London 1976.
Rosenstreich, D. L., Glode, L. M., Walsh, L. M., Sandberg, A. L., and Mergenhagen, S. E., in: Microbiology, p. 314–320. Ed. D. Schlessinger. American Society Microbiology, Washington, D.C. 1977.
Shade, U. F., Luderitz, T., and Reitschel, E. M., Riva immun. immunofarmac.6(35) (1986) 103.
Morris, D. C., A. Rev. Med.38 (1987) 417.
Terashita, Z. I., Imura, Y., Nishikawa, K., and Sumida, S., Eur. J. Pharmac.109 (1985) 257.
Freudenberg, M. A., Keppler, D., and Galamos, C., Infect. Immun.51 (1986) 891.
West, M. A., Keller, G. A., Hyland, B. J., Cerra, F. B., and Simmons, R. L., Surgery98 (1985) 388.
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Stark, J.M., Jackson, S.K., Taylor, S. et al. The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice. Experientia 46, 472–474 (1990). https://doi.org/10.1007/BF01954235
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DOI: https://doi.org/10.1007/BF01954235