Summary
The role of vasoactive intestinal peptide (VIP), as a possible neurotransmitter of the intrinsic nerve plexus in the guinea pig gallbladder, was investigated by monitoring spontaneous contractile activity. VIP receptor antagonist (4 Cl-D-Phe6, Leu17)-VIP did not produce any effect on muscular tone and spontaneous activity, whereas (N-Ac-Tyr1, D-Phe2)-GRF-(1-29)-NH2, (14-GRF analog), which is known to stimulate digestive enzyme secretion by interacting with the VIP-preferring receptors, greatly increased the amplitude and frequency of waves as well as the muscular tone. Since VIP receptor antagonist acts selectively as a competitive antagonist for the action of VIP, we conclude that the gallbladder inhibitory intrinsic plexus neurotransmitter is not VIP, but a member of the glucagon-secretin family of peptides.
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References
Davison, J. S., Al-Hassani, M., Crowe, R., and Burnstock, G., Pflügers Arch.377 (1978) 43.
Davison, J. S., and Al-Hassani, M., in: Gastrointestinal Motility, p. 89. Ed. J. Christensen. Raven Press, New York 1980.
Larsson, L. I., Fahrenkrug, J., Schaffalitzky, De Muckadell, O., Sundler, F., Hakanson, R., and Rehfeld, J. F., Proc. natl Acad. Sci. USA73 (1976) 3197.
Bryant, M. G., Bloom, S. R., Polak, J. M., Albuquerque, R. H., Modlin, J., and Pearse, A. G. E., Lancet1 (1976) 991.
Sundler, F. J., Alumets, J., Hakanson, R., Ingemansson, S., Fahrenkrug, J., Schaffalitzky, D., and Muckadel, O., Gastroenterology72 (1977) 1375.
Jansson, R., Steen, G., and Svanvik, J., Gastroenterology75 (1978) 47.
Said, S. J., Gastroenterology67 (1974) 735.
Said, S. J., and Makhlouf, G. M., in: Endocrinology of the Gut, p. 83. Eds W. J. Chey and F. P. Brooks. C. B. Slack, Thorofare, NJ 1974.
Pandol, S. J., Seifert, H., Thomas, M. W., Rivier, J., and Vale, W., Science225 (1984) 326.
Pandol, S. J., Dharmsathaphorn, K., Schoeffield, M. S., Vale, W., and Rivier, J., Am. J. Physiol.250 (1986) G553.
Mancinelli, R., Racanicchi, C., Mingrone, G., Arcieri-Mastromattei, E., and Greco, A. V., Q. J. exp. Physiol.74 (1989) 429.
Said, S. J., and Mutt, V., Science169 (1970) 1217.
Said, S. J., and Mutt, V., Eur. J. Biochem.28 (1973) 199.
Piper, P. J., Said, S. J., and Vane, J. P., Nature225 (1970) 1144.
Vagne, M., and Troitskoja, V., Digestion14 (1976) 62.
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Greco, A.V., Mancinelli, R., Mingrone, G. et al. A glucagon-secretin-like peptide stimulates the intrinsic nervous plexus of guinea pig gallbladder. Experientia 46, 452–454 (1990). https://doi.org/10.1007/BF01954226
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DOI: https://doi.org/10.1007/BF01954226