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Plasma endothelin-1 like immunoreactivity levels in neonates

  • Neonatology
  • Published:
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Abstract

We attempted to determine the plasma endothelin-1-like immunoreactivity (ET-1) levels and to evaluate its physiological significance in 29 neonates: 5 with respiratory distress syndrome (RDS), 3 with transient tachypnoea of the newborn (TTN), 4 with neonatal asphyxia, 5 with bronchopulmonary dysplasia (BPD) following RDS, 7 healthy preterm infants and 5 healthy full-term infants. Plasma ET-1 levels in infants with RDS were significantly higher than those in healthy full-term infants through the 1st week of life. Plasma ET-1 levels in infants with neonatal asphyxia were high on the first 2 days of life and then gradually decreased to those of healthy full-term infants. Plasma levels in infants with TTN were the same as those in healthy full-term infants. Plasma ET-1 levels in infants with BPD were high when compared with those in healthy preterm infants during the first 2 months of life. This study showed that plasma levels were markedly elevated for a long time in the infants with respiratory distress. We speculate that plasma ET-1 may be a specific marker for pulmonary endothelium injury in infants with respiratory distress.

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Abbreviations

BPD:

bronchopulmonary dysplasia

ET-1:

endothelin-1-like immunoreactivity

RDS:

respiratory distress syndrome

TFA:

trifluoroacetic acid

TTN:

transient tachypnoea

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Authors and Affiliations

  1. Department of Paediatrics, Kansai Medical University, Fumizonocho 1, Moriguchi, 570, Osaka, Japan

    T. Kojima, Y. Isozaki-Fukuda, M. Takedatsu, A. Ono & Y. Kobayashi

  2. Second Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Yushima, Bunkyoku, 113, Tokyo, Japan

    Y. Hirata

Authors
  1. T. Kojima
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  2. Y. Isozaki-Fukuda
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  3. M. Takedatsu
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  4. A. Ono
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  5. Y. Hirata
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  6. Y. Kobayashi
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Kojima, T., Isozaki-Fukuda, Y., Takedatsu, M. et al. Plasma endothelin-1 like immunoreactivity levels in neonates. Eur J Pediatr 151, 913–915 (1992). https://doi.org/10.1007/BF01954129

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  • DOI: https://doi.org/10.1007/BF01954129

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