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The effects of scorpion venom tityustoxin and ouabain on the release of acetylcholine from incubated slices of rat brain

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Summary

The in vitro release of acetylcholine in slices of rat brain tissue was followed in the presence of tityustoxin and ouabain. At low ouabain concentrations, the release of acetylcholine caused by both ouabain and tityustoxin, was additive. At higher ouabain concentrations the additive effect of tityustoxin and ouabain on the release of ACh was no longer observed.

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Authors and Affiliations

  1. Department of Biochemistry and Immunology, Institute of Biological Sciences, P.O. Box 2486-UFMG, Belo Horizonte, Minas Gerais, Brasil

    M. V. Gomez

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  1. M. V. Gomez
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Additional information

Supported by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). We wish to thank Miss Terezinha Stockler Barbosa and Mr Antonio Soares Usual dos Santos for expert technical assistance. We thank Dr J.R. Pleasant for reading this manuscript.

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Gomez, M.V. The effects of scorpion venom tityustoxin and ouabain on the release of acetylcholine from incubated slices of rat brain. Experientia 36, 1007–1008 (1980). https://doi.org/10.1007/BF01953851

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  • DOI: https://doi.org/10.1007/BF01953851

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