Experientia

, Volume 35, Issue 12, pp 1631–1632 | Cite as

Thioridazine and EKG anomalies

  • B. Hine
  • L. J. Traficante
  • G. Sakalis
  • S. Gershon
Article

Summary

Acute i.v. infusion but not daily oral administration of thioridazine-HCl in the dog produced EKG anomalies similar to those reported in psychiatric patients taking this drug. Lack of EKG effects after thioridazine-5-sulfoxide infusion and presence of anomalies after thioridazine at equivalent doses suggests further evaluation of the relationship between reported plasma levels of thioridazine and its ring-sulfoxide in association with EKG changes.

Keywords

Plasma Level Oral Administration Equivalent Dose Psychiatric Patient Thioridazine 

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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • B. Hine
    • 1
  • L. J. Traficante
    • 1
  • G. Sakalis
    • 1
  • S. Gershon
    • 1
  1. 1.Department of PsychiatryNew York University School of MedicineNew YorkUSA

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