Summary
Transient sympathetically-mediated depressor effects were induced by stimulation of a small locus in the lateral hypothalamic peri-fornical region, medial to the fields of Forel. The ganglionic blocking agent, atropine methyl nitrate (ATMN), was used to show that muscarinic as well as non-muscarinic sympathetic ganglion receptor neurotransmission was involved. Evidence is presented that stimulation of this LH site co-activates a number of mechanisms and that depending on which of these are activated, the ganglionic blocking agent ATMN may either block, reverse or potentiate the depressor effect.
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Literature
Bernthal, P. J., and Koss, M. C., Neuropharmacology23 (1984) 31.
Bleir, R., The Hypothalamus of the Cat. A Cytoarchitectonic Atlas with Horsley-Clarke Coordinates. The John Hopkins Press, Baltimore USA 1961.
Blum, B., Weinstock, M., Israeli, J., Motles, E., Davidovich, Z., Farchi, M. and Mihiz, M., Eur. J. Pharmac.88 (1983) 301.
Blum, B., Israeli, J., Mihich, M., and Farchi, M., J. Physiol. (London)358 (1984) 124.
Blum, B., Israeli, J., Hart, O., Mihiz, M., and Farchi, M., Experientia43 (1987) 1106.
Coote, J. H., and MacLeod, V. H., J. Physiol. (London)241 (1974) 477.
Fagius, J., and Wallin, B. G., Brain106 (1983) 589.
Flacke, W., and Gillis, R. A., J. Pharmac. exp. Ther.163 (1968) 266.
Gebber, G. L., Taylor, D. G., and Weaver, L. C., Am. J. Physiol.224 (1973) 470.
Hess, W. R., Beiträge zur Physiologie des Hirnstammes. I. Die Methodik der lokalizierten Reizung und Ausschaltung subkortikaler, Hirnabschnitte. George Thieme, Leipzig 1954.
Hilton, S. M., J. Physiol. (London)165 (1963) 56.
Kirchheim, H. R., Physiol. Rev.56 (1976) 100.
Koizumi, K., and Brooks, C. McC., Ergeb. Physiol.67 (1972) 1.
Libet, B., Slow synaptic actions in ganglionic functions, in: Integrative Functions of the Autonomic Nervous System, pp. 197–222. Eds C. M. Brooks, K. Koizumi and A. Sato. Elsevier, Amsterdam 1979.
Libet, B., Nonclassical synaptic functions of transmitters, in: Symposium on Historical and Modern Prespectives in Neurophysiology. Am. Physiol. Soc., 68th Am. Meet. Soc. Eng. Biol., St. Louis, MI. April, 1984.
Shy, G. M., and Drager, G. A., Arch. Neur.2 (1960) 511.
Young, R. R., Ashbury, A. K., Corbett, J. L., and Adams, R. D., Brain98 (1975) 613.
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Blum, B., Israeli, J., Hart, O. et al. Depressor effects of muscarinic and non-muscarinic mediation induced by lateral hypothalamic stimulation in the rat. Experientia 45, 991–996 (1989). https://doi.org/10.1007/BF01953059
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DOI: https://doi.org/10.1007/BF01953059