Abstract
Haptoglobin (Hp) development during the neonatal period has been studied in 325 newborn infants from normal pregnancies and in 242 infants from diabetic mothers. In infants from diabetic mothers Hp development is delayed as compared to infants from normal pregnancies. This delay is associated with a change in the pattern of relationship between Hp development and the polymorphism of acid phosphatase (ACP1) (an enzyme which shows phosphotyrosine phosphatase (PTPase) activity). In infants from normal pregnancies who show ACP1 phenotypes with the highest activity, the appearance of Hp is accelerated as compared to other infants. In contrast, infants from diabetic pregnancies who have ACP1 phenotypes with the highest activity, show delayed Hp development.
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Horton, W. E. Jr, and Sadler, W., Diabetes32 (1983) 610.
Bard, H., and Prosmanne, J., Pediatrics75 (1985) 1143.
Perrine, S., Greene, M., and Faller, D. V., New Engl. J. Med.312 (1985) 334.
Perrine, S. P., Miller, B. A., Greene, M. F., Cohen, R. A., Cook, N., Shackleton, C., and Faller, D. V., Biochim. Biophys. Res. Commun.148 (1987) 694.
Philip, A. G. S., Biologia Neonat.19 (1971) 185.
Philip, A. G. S., Biologia Neonat.19 (1971) 322.
Toivo, T. S., Acta paediat. scand.Suppl. 241 (1973) 7.
Eaton, J. W., Brandt, P., Mahoney, J. R., and Lee, J. T. Jr, Science215 (1982) 691.
Wo Yu-Yuan, P., McCormack, A. L., Shabanowitz, J., Hunt, D. F., and Davista, J. P., J. biol. Chem.267 (1992) 10856.
National Diabetes Data Group. Diabetes28 (1979) 1039.
Bottini, E., Gerlini, F., Fallucca, F., Lucarini, N., Bonci, E., Arachi, S., and Gloria-Bottini, F., Dis. Markers3 (1985) 83.
Harris, H., Hopkinson, D. A., Handbook of Enzyme Electrophoresis in Human Genetics. Elsevier, Amsterdam 1976.
Maeda, N., and Smithies, O., A. Rev. Genet.20 (1986) 81.
Maeda, N., Am. J. hum. Genet.49 (1991) 158.
Oliviero, S., and Cortese, R., Embo. J.8 (1989) 1145.
Bottini, E., Carapella, E., Scacchi, R., Lucarini, N., Gloria-Bottini, F., Pascone, R., Bonci, E., Maggioni, G., Early hum. Dev.10 (1985) 237
Ward, R. D., Sarfarazi, M., Azimi-Garakani, C., and Beardmore, J. A., in: Genetic and Population Studies in Wales, p. 342. Eds P. S. Harper and E. Sunderland. University of Wales Press, Cardiff 1986.
Gloria-Bottini, F., Gerlini, G., Lucarini, N., Borgiani, P., Gori, M. C., Amante, A., Lucarelli, P., and Bottini, E., Early hum. Dev.17 (1988) 265.
Amante, A., Gloria-Bottini, F., and Bottini, E. J., Perinat. Med.18 (1990) 275.
Bottini, E., Scacchi, R., Gloria-Bottini, F., Mortera, J., Palmarino, R., Carapella-De Luca, E., Lapi, A. S., and Nodari, S., Lanceti (1976) 918.
Hopkinson, D. A., Spencer, N., and Harris, H., Nature199 (1963) 696.
McKusick, V. A., Mendelian Inheritance in Man. Ninth Edition, John Hopkins University Press, Baltimore, USA 1990.
Spencer, N., Hopkinson, D. A., and Harris, H., Nature201 (1964) 299.
Camici, G., Manao, G., Cappugi, G., Modesti, A., Stefani, M., and Ramponi, G., J. biol. Chem.264 (1989) 2560.
Dissing, J., and Svensmark, O., Biochim. biophys. Acta1041 (1990) 232.
Dissing, J., Johnsen, A. H., and Sensabaugh, C. F., J. biol. Chem.266 (1991) 20619.
Manao, G., Pazzagli, L., Cirri, P., Caselli, A., Camici, G., Cappugi, G., Saeed, A., and Ramponi, G., J. Protein Chem.11 (1992) 333.
Boivin, P., and Galand, C., Biochem. biophys. Res. Commun.134 (1986) 557.
Mansfield, E., and Sensabaugh, G. F., in: The Red Cell, p. 233 (Progr. Biol. Res. 21). Ed. G. J. Brewer. Alan R. Liss, New York 1978.
Kimberley Fuchs, R., Shekels, L., and Bernlohr, D. A., Biochem. Biophys. Res. Commun.189 (1992) 1598.
Ramponi, G., Manao, G., Camici, G., Cappugi, G., Ruggiero, M., and Bottaro, D. P., FEBS Letts250 (1989) 469.
Ramponi, G., Ruggiero, M., Raugei, G., Berti, A., Modesti, A., Degl'Innocenti, D., Magnelli, L., Pazzagli, C., Chiarugi, V. P., and Camici, G., Int. J. Cancer51 (1992) 652.
Vogel, W., Lammers, R., Huang, J., and Ullrich, A., Science259 (1993) 161.
Sensabaugh, G. F., and Golden, V. L., Am. J. hum. Genet.30 (1978) 553.
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Borgiani, P., Gloria-Bottini, F., Gerlini, G. et al. Haptoglobin development in newborn infants from diabetic mothers. Experientia 50, 687–690 (1994). https://doi.org/10.1007/BF01952875
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DOI: https://doi.org/10.1007/BF01952875