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Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats

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Summary

The weight of the stomach, small intestine and colon and the mucosal crypt cell production rate of these tissues were significantly decreased after 10 days on an isocaloric TPN diet when compared to orally fed controls. Continuous infusion of recombinant beta urogastrone, at a dose below that needed to inhibit gastric acid secretion, largely prevented this decrease in crypt cell production rate and gastrointestinal tissue weights.

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Author notes

  1. H. Gregory

    Present address: ICI, Alderley Park, Macclesfield

  2. K. G. McCullough

    Present address: , High Wycombe, Bucks

Authors and Affiliations

  1. Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London, England

    R. A. Goodlad, T. J. G. Wilson, W. Lenton, H. Gregory, K. G. McCullough & N. A. Wright

Authors
  1. R. A. Goodlad
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  2. T. J. G. Wilson
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  3. W. Lenton
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  4. H. Gregory
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  5. K. G. McCullough
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  6. N. A. Wright
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Goodlad, R.A., Wilson, T.J.G., Lenton, W. et al. Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats. Experientia 41, 1161–1163 (1985). https://doi.org/10.1007/BF01951708

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  • DOI: https://doi.org/10.1007/BF01951708

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