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Pancreatic polypeptide: A possible role in the regulation of food intake in the mouse. Hypothesis

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Summary

Pancreatic polypeptide (PP) is a recently identified hormone produced by pancreatic endocrine cells. The islets of genetically obese mice (ob/ob, C57 BL/6J), which are suspected to lack a circulating satiety factor, contain relatively few of the PP-producing cells. Administration of bovine pancreatic polypeptide (bPP) reduces food intake and suppresses body weight gain in the hyperphagic obese mice. It is postulated that PP participates in the regulation of food intake in a manner as yet undefined.

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Author notes

  1. Y. C. Patel

    Present address: Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia

  2. W. J. Malaisse

    Present address: Laboratory of Experimental Medicine, Brussels University, Brussels, Belgium

Authors and Affiliations

  1. Institute of Histology and Embryology, Geneva University School of Medicine, CH-1211, Genève 4, Switzerland

    Francine Malaisse-Lagae, J. -L. Carpentier, Y. C. Patel, W. J. Malaisse & L. Orci

Authors
  1. Francine Malaisse-Lagae
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  2. J. -L. Carpentier
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  3. Y. C. Patel
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  4. W. J. Malaisse
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  5. L. Orci
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Additional information

This work was supported by grant No. 3.553.75 from Swiss National Science Foundation. We thank Mrs M. Eissler and Mr R. Cuche for their valuable help.

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Malaisse-Lagae, F., Carpentier, J.L., Patel, Y.C. et al. Pancreatic polypeptide: A possible role in the regulation of food intake in the mouse. Hypothesis. Experientia 33, 915–917 (1977). https://doi.org/10.1007/BF01951279

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  • DOI: https://doi.org/10.1007/BF01951279

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