Skip to main content
SpringerLink
Log in

Paratopic interaction, a mechanism in the generation of structure bound enzymatic activity

  • Specialia
  • Chimica, Biochimica
  • Published:
Experientia Aims and scope Submit manuscript

Summary

A general mechanism is recognized that can cause specific enzymatic activity at interphases. It consists of 2 proteins bound in close juxtaposition at a micelle or membrane surface. One, the enzymesensu strictu, bears the active site, the other, the paraenzyme, is essential for generation or specific modification of the enzymatic activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. Monod, J. P. Changeux and F. Jacob, J. molec. Biol.6, 306 (1963).

    Article  CAS  PubMed  Google Scholar 

  2. J. Monod, J. Wyman and J. P. Changeux, J. molec. Biol.12, 88 (1965).

    Article  CAS  PubMed  Google Scholar 

  3. E. Racker, Fedn. Proc.26, 1335 (1967).

    CAS  Google Scholar 

  4. C. Haanen, G. Morselt and J. Schoenmakers, Thromb. Diath. haemorrh.17, 307 (1967).

    CAS  PubMed  Google Scholar 

  5. D. Papahadjopoulos and D. J. Hanahan, Biochim. biophys. Acta90, 436 (1964).

    Article  CAS  PubMed  Google Scholar 

  6. E. R. Cole, J. L. Koppel and J. H. Olwin, Thromb. Diath. haemorrh.14, 431 (1965).

    CAS  PubMed  Google Scholar 

  7. M. J. P. Kahn, Thesis, Leiden 1970.

  8. H. C. Hemker, M. P. Esnouf, P. W. Hemker, A. C. W. Swart and R. G. Macfarlane, Nature215, 248 (1967).

    Article  CAS  PubMed  Google Scholar 

  9. F. Jobin and M. P. Esnouf, Biochem. J.102, 666 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. W. J. Williams and M. P. Esnouf, Biochem. J.84, 52 (1962).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. H. C. Hemker and M. J. P. Kahn, Nature215, 1201 (1967).

    Article  CAS  PubMed  Google Scholar 

  12. P. J. Lachmann. Proc. R. Soc. B.173, 371 (1969).

    CAS  Google Scholar 

  13. P. J. Lachmann, in: Clinical Aspects of Immunology. Ed. P. G. H. Gell and R. R. A. Coombs. Blackwell Scientic Publ. London.

  14. H. J. Müller-Eberhard, Adv. Immun.8, 1 (1968).

    Article  PubMed  Google Scholar 

  15. Y. Kagawa and E. Racker, J. biol. Chem.241, 2461 (1966).

    Article  CAS  PubMed  Google Scholar 

  16. Y. Kagawa and E. Racker, J. biol. Chem.241, 2467 (1966).

    Article  CAS  PubMed  Google Scholar 

  17. B. Bulos and E. Racker, J. biol. Chem.243, 3891 (1968).

    Article  CAS  PubMed  Google Scholar 

  18. A. Bruni and E. Racker, J. biol. Chem.243, 962 (1968).

    Article  CAS  PubMed  Google Scholar 

  19. M. P. Esnouf, in: Human Blood Coagulation. Ed. H. C. Hemker, E. A. Loeliger and J. J. Veltkamp. Leiden University Press 1969.

Download references

Author information

Author notes

  1. H. L. L. Frank

    Present address: Department of Cardiology, St. Annadal Hospital, Maastricht, The Netherlands

Authors and Affiliations

  1. Department of Biochemistry, Biomedical Centre, State University Limburg, NL-Maastricht, The Netherlands

    H. C. Hemker & H. L. L. Frank

Authors
  1. H. C. Hemker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. L. L. Frank
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hemker, H.C., Frank, H.L.L. Paratopic interaction, a mechanism in the generation of structure bound enzymatic activity. Experientia 33, 851–853 (1977). https://doi.org/10.1007/BF01951238

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01951238

Keywords

Search

Navigation