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Morphological effects of prostaglandins E1, E2 and F2α on fibroblast-like cultures of human synovial cells

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Summary

In medium supplemented with serum, PGE1 and PGE2 were equally potent in inducing cells with a fenestrated appearance, whereas PGF2α was comparatively ineffective. In BSA without serum the effects were more persistent and characterized by a high proportion of astrocyte-like cells. The effects were reversed upon removal of the prostaglandins.

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References

  1. N. Williamson, K. James, N. R. Ling and L. P. Holt, Ann. rheum. Dis.25, 534 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. P. Barland, A. B. Novikoff and D. Hamerman, J. Cell Biol.14, 207 (1962).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. J. R. E. Fraser, B. J. Clarris and E. Baxter, Ann. rheum. Dis.38, 287 (1979).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. J. LeMarshall, J. R. E. Fraser and K. D. Muirden, Ann. rheum. Dis.36, 130 (1977).

    Article  CAS  Google Scholar 

  5. F. A. Kuehl, Prostaglandins5, 325 (1974).

    Article  CAS  PubMed  Google Scholar 

  6. J. R. E. Fraser and K. J. Catt, Lancet2, 1437 (1961).

    Article  CAS  PubMed  Google Scholar 

  7. J. R. E. Fraser and J. F. McCall, Ann. rheum. Dis.24, 351 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. B. J. Clarris and J. R. E. Fraser, Aust. J. exp. Biol. med. Sci.45, 549 (1967).

    Article  CAS  PubMed  Google Scholar 

  9. C. W. Castor, J. Lab. clin. Med.85, 392 (1975).

    CAS  PubMed  Google Scholar 

  10. J. R. Dedman, B. R. Brinkley and A. R. Means, Adv. cyclic nucl. Res.11, 131 (1979).

    CAS  Google Scholar 

  11. J. R. Ortiz, T. Yamada and A. W. Hsie, Proc. natl Acad. Sci. USA70, 2286 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Royal Melbourne Hospital, University of Melbourne, 3050, Parkville, Victoria, Australia

    B. J. Clarris

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  1. B. J. Clarris
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This work was supported by the National Health and Medical Research Council of Australia.

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Clarris, B.J. Morphological effects of prostaglandins E1, E2 and F2α on fibroblast-like cultures of human synovial cells. Experientia 38, 350–351 (1982). https://doi.org/10.1007/BF01949386

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  • DOI: https://doi.org/10.1007/BF01949386

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