Abstract
The effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on dopamine (DA) release and metabolism in the striatum was studied in freely moving rats by intracerebral microdialysis techniques. The DA level as well as the levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly decreased 140 min after the administration of L-threo-DOPS (50 mg/kg intraperitoneally). The results suggest that L-threo-DOPS inhibits the release and metabolism of DA in the striatum.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Nagatsu, T., Kato, T., Nagatsu, I., and Kondo, Y., in: Advances in Neurology, vol. 24, p. 283. Eds L. J. Poirier, T. L. Sourkes and P. J. Bedard. Raven Press, New York 1979.
Narabayashi, H., Kondo, T., Hayashi, A., Suzuki, T., and Nagatsu, T., Proc. Japan Acad.58 (1981) 351.
Westerink, B. H. C., Damsma, G., Rollema, H., D. E. Vries, J. B. Horn, and Horn, A. S., Life Sci.41 (1987) 1763.
Yokoo, H., Tanaka, M., Yoshida, M., Tsuda, A., Tanaka, T., and Mizoguchi, K., Brain Res.536 (1990) 305.
Paxinos, G., and Watson, C., The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney 1982.
Man in't Veld, A. J., Boomsma, F., Van der Meiracker, A. H., and Schalekamp, M. A. D. H., Lancet2 (1987) 1172.
Foreman, M. M., and Porter, J. C., J. Neurochem.34 (1980) 1175.
Everett, G. M., and Borcherding, J. W., Science168 (1970) 849.
Grzanna, R., Morrison, J. H., Coyle, J. T., and Molliver, M. E., Neurosci. Lett.4 (1977) 127.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mizoguchi, K., Tanaka, M., Yokoo, H. et al. L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, inhibits dopamine release and metabolism in the rat striatum in vivo. Experientia 48, 1133–1134 (1992). https://doi.org/10.1007/BF01948006
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01948006