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Lanthanum inhibits Ca inward current but not Na-Ca exchange in cardiac muscle

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Zusammenfassung

In Herzmuskelpräparaten sind zwei Systeme für den Ca-Durchtritt durch die Plasmamembranen zu unterscheiden: 1. Ein spannungs- und zeitabhängiger Ca-Einwärtsstrom, der während der Plateauphase des Aktionspotentials fliesst und durch La3+ gehemmt wird; 2. ein Na−Ca-Austauschsystem, das vor allem für den Auswärtstransport von Ca aus der Zelle verantwortlich ist, und durch La3+ nicht beeinflusst wird.

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Author notes

  1. B. G. Katzung

    Present address: Department of Pharmacology, University of California, San Francisco Medical Center, 94122, San Francisco, Calif., USA

Authors and Affiliations

  1. Pharmakologisches Institut der Universität Bern, Friedbühlstrasse 49, CH-3008, Bern, Switzerland

    B. G. Katzung, H. Réuter & H. Porzig

Authors
  1. B. G. Katzung
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  2. H. Réuter
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  3. H. Porzig
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Katzung, B.G., Réuter, H. & Porzig, H. Lanthanum inhibits Ca inward current but not Na-Ca exchange in cardiac muscle. Experientia 29, 1073–1075 (1973). https://doi.org/10.1007/BF01946727

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  • DOI: https://doi.org/10.1007/BF01946727

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