Recent immunological research has concentrated on the complex and subtle interactions between T cells, B cells and accessory cells. In these studies, little attention has been given to the adult thymus gland. Modern textbooks of disease and anatomy all stress that the gland undergoes fatty involution with age in man but omit reference to the statements here and there in the literature that the gland is active and produces lymphocytes throughout life. To suggest that the bone marrow, which also builds up fat throughout life, is atrophic and not important to adult man would deny all modern hematological concepts. Yet few people today take a parallel view of the thymus except perhaps those investigating aging and thymic hormones. In both of these areas of research it is obvious that the thymus must be active throughout life for continued good health. This brief review urges that a thorough understanding of the vital importance of the thymus in adult life is now needed. From it could emerge a new philosophy on the treatment of immune diseases in both the young (SCID and AIDS patients) and in the aged (autoimmune conditions and cancers) and it would aid our treatment of patients recovering from illnesses and from many drug treatments.
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Alexander, J. W., and Good, R. A., Fundamentals of clinical immunology, Saunders, Philadelphia 1977.
Alexopoulos, C., and Babitis, P., Age dependance of T lymphocytes. Lancet1 (1976) 426.
Andreasen, E., Studies on the thymolymphatic system. Quantitative investigations on the thymolymphatic system in normal rats at different ages, under normal conditions and during inanition and restitution after starvation. Acta path. microbiol. scand. suppl.49 (1943) 1–171.
Aschkenasy, A., Role played by thymus atrophy in disorders of immunological reactions to sheep red blood cells and rosette cells in protein-deficient rats. Ann. Immun., Paris124 (1973) 345–362.
Bach, J. F., Dardenne, M., and Davies, A. J. S., Early effect of adult thymectomy. Nature New Biol.231 (1971) 110–111.
Bloodworth, J. M. B., Endocrine pathology. Williams & Wilkins, Baltimore and London 1982.
Boyd, E., The weight of the thymus gland in health and disease. Am. J. Dis. Child.43 (1932) 1162–1214.
Bratton, A. B., The normal weight of the human thymus. J. Path. Bact.28 (1925) 609–620.
Bryant, B. J., Renewal and fate in the mammalian thymus: mechanisms and inferences of thymocytokinetics. Eur. J. Immun.2 (1972) 38–48.
Burnett, F. M., New horizons in the role of zinc in cellular proliferation, in: Clinical applications of recent advances in zinc metabolism, pp. 181–192. Eds A. S. Prasad, I. E. Dreosti and B. S. Hetzel. Alan R. Liss, New York 1982.
Cantor, H., and Weissman, I., Development and function of subpopulations of thymocytes and T lymphocytes. Prog. Allergy20 (1976) 1–64.
Chatamra, K., Daniel, P. M., Kendall, M. D., and Lam, D. K. C., A preliminary report on the histological changes in the thymus found in rats rendered diabetic with streptozotocin. J. Anat.137 (1983) 413.
Cowan, W. K., and Sorenson, G. D., Electron microscopic observations of acute thymic involution produced by hydrocortisone. Lab. Invest.13 (1964) 353–370.
Cronkite, E. P., Effects of extracorporeal irradiation of blood and lymph upon the lymphoreticular system, in: La circulation lymphocytaire chez l'homme, p. 26, Société Française d'Hématologie, Paris 1968.
Dardenne, M., and Bach, J-F., Thymic hormones, in: The Thymus, pp. 113–131. Ed. M. D. Kendall. Academic Press, London 1981.
Dougherty, T. F., The effect of hormones on lymphatic tissue. Phys. Rev.32 (1952) 379–401.
Edwards, A. J., Summer, M. R., Rowland, G. F., and Hurd, C. M., Changes in lymphoreticular tissues during growth of a murine adenocarcinoma. I. Histology and weight of lymph nodes, spleen and thymus. J. natl Cancer Inst.47 (1971) 301–311.
El Hassan, A. M., and Stuart, A. E., Changes in lymphoreticular tissue of mice bearing the Landschütz tumour. Br. J. Cancer19 (1965) 343–352.
Fabrikant, J. I., and Foster, B. R., Cell population kinetics in lymphocytes in mouse and rat thymus. Johns Hopkins med. J.130 (1972) 208–215.
Foege, W. H., Famine, infections and epidemics, in: Famine — a symposium dealing with malnutrition and relief operations in times of disaster. Eds G. Blix, Y. Hofvander and B. Vahlqvist. Symp. Swedish Nutrit. Foundation9 (1971) 64–73.
Gad, P., and Clark, S. L. Jr, Involution and regeneration of the thymus in mice, induced by bacterial endotoxin and studied by quantitative histology and electron microscopy. Am. J. Anat.122 (1968) 573–606.
Goldstein, G., Abbot, A., and MacKay, I. R., An electron microscope study of the human thymus: normal appearances and findings in myasthenia gravis and systemic lupus erythematosus. J. Path. Bact.95 (1968) 211–215.
Goldstein, G., and MacKay, I. R. The human thymus. Heinemann Medical, London 1969.
Good, R. A., and Gabrielson, A. E., The thymus in immunobiology. Structure, function and role in disease. Hoeber Medical Division, Harper & Row, New York and London 1964.
Hammar, J. A., Zur Histogenese und Involution der Thymusdrüse. Anat. Anz.27 (1905) 23–30 and 41–89.
Hammar, J. A., Über Gewicht, Involution und Persistenz der Thymus in Postfoetalleben des Menschen. Arch. Anat. Phys. Anat., Leipzig (1906) 91–92.
Hammar, J. A., The new views as to the morphology of the thymus gland and their bearing on the problem of the function of the thymus. Endocrinology5 (1921) 545–573 and 731–760.
Harris, P. F., Changes in thymus and lymph node activity, and alterations in bone marrow lymphocyte levels during recovery of the guinea-pig from whole body gamma irradiation. Br. J. exp. Path.34 (1958) 557–573.
Höhn, E. O., Seasonal cyclical changes in the thymus of the mallard. J. exp. Biol.24 (1947) 184–191.
Huldt, G., Gard, S. and Olovson, S. G., Effect ofToxoplasma gondii on the thymus. Nature244 (1973) 301–303.
Hünig, T., T-cell function and specificity in athymic mice, in T-lymphocytes today, p. 42–45. Ed. J. R. Inglis, Elsevier/North Holland, Amsterdam 1983.
Inamura, M., Matsuyama, T., Toh, K., and Okuyama, T., Electron microscopic study on acute thymic involution induced by polyoma virus infection. J. natl Cancer Inst.47 (1971) 289–300.
Ito, T., and Hoshino, T., Histological changes of the mouse thymus during involution and regeneration following administration of hydrocortisone. Z. Zellforsch.56 (1962) 445–464.
Jackson, C. M., The effects of inanition and malnutrition upon growth and structure. Blakiston, Philadelphia 1925.
Jordan, R. K., and Robinson, J. H., T lymphocyte differentiation, in: The Thymus, pp. 151–177. Ed. M. D. Kendall. Academic Press, London 1981.
Kendall, M. D., The cells of the thymus, in: The Thymus, pp. 63–83. Ed. M. D. Kendall, Academic Press, London 1981.
Kendall, M. D., and Blackett, N. M., Ultrastructural studies on the thymus gland after the administration of phenylhydrazine to bank voles (Clethrionomys glareolus). Cell Tissue Res.232 (1983) 201–219.
Kendall, M. D., Johnson, H. R. M., and Singh, J., The weight of the human thymus gland at necropsy. J. Anat.131 (1980) 485–499.
Kendall, M. D., and Ward, P., Erythopoiesis in an avian thymus. Nature249 (1974) 366–367.
Keynes, G., The physiology of the thymus gland. Br. med. J.1 (1954) 659–663.
Koller, L. D., Immunosuppression produced by lead, cadmium and mercury. Am. J. vet. Res.34 (1973) 1457–1458.
Kotani, M., Seiki, K., Yamashita, A., and Horii, I., Lymphatic drainage of thymocytes to the circulation in the guinea pig. Blood27 (1966) 511–520.
Labreque, P. G., Souadjian, J. V., and Titus, J. L., Quantitative morphological study of the human thymus in a series of autopsies. Union Med. Can.101 (1972) 695–697.
Le Douarin, N. M., and Jotereau, F. V., The ontogeny of the thymus; in: The Thymus, pp. 37–62. Ed. M. D. Kendall. Academic Press, London 1981.
Linna, T. J., Cell migration from the thymus to other lymphoid organs in hamsters of different ages. Blood31 (1968) 727–746.
Loor, F., and Kindred, B., Differentiation of T-cell precursors in nude mice demonstrated by immunofluorescence of T-cell membrane markers. J. exp. Med.138 (1973) 1044–1055.
Lundin, M., and Schelin, U., The effect of steroids on the histology and ultrastructure of lymphoid tissue. Path. eur.1 (1966) 15–28.
MacKay, I. R., Histopathology of the human thymus, in: The thymus: experimental and clinical studies. A CIBA Foundation Volume. Eds G. E. N. Woolstenholme and R. J. A. Porter. Churchill, London 1966.
Manning, M. J., A comparative view of the thymus in vertebrates, in: The Thymus, pp. 7–20. Ed. M. D. Kendal. Academic Press, London 1981.
Marine, D., Mandey, O. T., and Baumann, E. J., The influence of thyroidectomy, gonadectomy, supra renalectomy and splenectomy on the thymus gland of rabbits. J. exp. Med.40 (1924) 429–441.
Matsuyama, M., Wiadrowski, M. N., and Metcalfe, D., Autoradiographic analysis of lymphopoiesis and lymphocyte migration in mice bearing multiple thymus grafts. J. exp. Med.123 (1966) 559–576.
McAnulty, P. A., and Dickerson, J. W., The cellular response of the weanling rat thymus gland to undernutrition and rehabilitation. Ped. Res.7 (9) (1973) 778–785.
McFarlane, H. and Hamid, J., Cell-mediated immune response in malnutrition. Clin. exp. Immun.13 (1973) 153–164.
McLean, J. M., Mosley, J. G., and Gibbs, A. C. C., Changes in the thymus, spleen and lymph nodes during pregnancy and lactation in the rat. J. Anat.118 (1974) 223–229.
McPhee, D., Pye, J., and Shortman, K., The differentiation of T-lymphocytes. V: Evidence for intrathymic death of most thymocytes. Thymus1 (1979) 151–162.
Metcalf, D., Delayed effect of thymectomy in adult life on immunological competence. Nature208 (1965) 1356.
Metcalf, D., and Wiadrowski, M., Autoradiographic analysis of lymphocyte proliferation in the thymus and thymic lymphoma tissue. Cancer Res.26 (1966) 483.
Michalke, W. D., Hess, M. W., Reidwyl, H., Stoner, R. D., and Cottier, H., Thymic lymphopoiesis and cell loss in new born mice. Blood33 (1969) 541–554.
Miller, J. F. A. P., The thymus: experimental and clinical studies. Eds G. E. W. Woolstenholme and R. Porter. Ciba Foundation Symposium. Churchill, London 1966.
Moynahan, E. J., Acrodermatitis enteropathica and the immunological role of zinc, in: Immunodermatology, pp. 437–447. Ed. B. Safai and R. A. Good Plenum Press, New York 1981.
Mugerwa, J. W., The lymphoreticular system in kwashiorkor. J. Path.105 (1971) 105–109.
Nelson, J. H. Jr, Hall, J. E., Manuel-Limson, G., Freiberg, H., and O'Brien, Fr. J., Effect of pregnancy on the thymolymphatic system. Am. J. Obstet. Gynec.98 (1967) 895–899.
Oksanen, A., Thymus in acute starvation and re-feeding, an experimental histoquantitative and statistical study in mice. Ann. Acad. Sci. Penn. (Biol.)181 (1971) 1–37.
Poste, M. E., and Olson, I. A., An investigation of the sites of mitotic activity in the guinea pig thymus using autoradiographic and colchemid-induced mitotic arrest. Immunology24 (1973) 691–697.
Pyke, K. W., and Gelfand, E. W., Morphological and functional malnutrition of human thymic epithelium in culture. Nature251 (1974) 421–423.
Sainte-Marie, G., and Peng, F. S., Emigration of thymocytes from the thymus — a review and study of the problem. Revue can. Biol.30 (1971) 51–78.
Santisteran, G. A., Riley, V., and Fitzmaurice, M. A., Thymolytic and adrenal cortical responses to the LDH-elevating virus. Proc. Soc. exp. Biol. Med.139 (1972) 202–206.
Scollay, R., Intrathymic events in the differentiation of T-lymphocytes: a continuing saga, in: T lymphocytes today, pp. 52–56. Ed. J. R. Inglis. Elsevier Science Publishers. Amsterdam 1983.
Scollay, R., Butcher, E., and Weissman, I. L., Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immun.10 (1982) 210–218.
Sharp, J. G., and Watkins, E. B., Cellular and immunological consequences of thymus irradiation, in: Immunopharmacological effects of radiotherapy. Ed. J. B. Dubois. Raven Press. New York 1980.
Simpson, J. G., Gray, E. S., and Beck, J. S., Age in ivolution in the normal human adult thymus. Clin. exp. Immun.19 (1975) 261–265.
Singh, J., Studies on the human thymus with particular reference to age changes. PhD Thesis, University of London 1980.
Sloan, H. E., Jr, The thymus in myasthenia gravis. With observations on the normal anatomy and histology of the thymus. Surgery13 (1943) 154–174.
Smythe, P. M., Schonland, M., Brereton-Stiles, G. G., Coovadia, H. M., Grace, H. J., Loenig, W. E. K., Mafoyane, A., Parent, M. A., and Vos, G. H., Thymolymphatic deficiency and depression of cellmediated immunity in protein calorie malnutrition. Lancet2 (1971) 939–944.
Stutman, O., Intrathymic and extrathymic T cell maturation. Immun. Rev.42 (1978) 138–184.
Taylor, R. B., Decay of immunological responsiveness after thymectomy in adult life. Nature208 (1965) 1334–1335.
Thompson, E. A., The effects of estradiol upon the thymus of the sexually immature female mouse. J. Steroid Biochem.14 (1981) 167–174.
Tosi, P., Kraft, R., Luzi, P., Cintorino, M., Fankhauser, G., Hess, M. W., and Cottier, H., Involution patterns of the human thymus. I. Size of the cortical area as a function of age. Clin. exp. Immun.47 (1982) 497–504.
Trainin, N., Pecht, M., and Handzel, Z-T., Thymic hormones: inducers and regulators of the T cell system. Immun. Today4 (1983) 16–21.
von Gaudecker, B., Ultrastructure of the age-involuted adult human thymus. Cell Tissue Res.186 (1978) 507–525.
Walford, R. L., Immunology and aging. Am. J. clin. Path.74 (1980) 247–253.
Ward, P., and Kendall, M. D., Morphological changes in the thymus of young and adult red-billed queleas (Quelea quelea) (Aves). Phil. Trans. R. Soc. B273 (1975) 55–64.
Watts, Th., Thymus wieghts in malnourished children. J. trop. Pediat.15 (1969) 155–158.
Webb, M., Metabolic targets of metal toxicity, in: Clinical chemistry and chemical toxicology of metals, pp. 51–64. Ed. S. S. Brown. Elsevier/North Holland Biomedical Press, Amsterdam 1977.
Weissman, I. L., Thymus cell migration. J. exp. Med.126 (1967) 291–304.
Young, M., and Turnbull, H., An analysis of the data collected by the Status Lymphaticus Investigation Committee. J. Path. Bact.34 (1931) 213–258.
Zaitoun, A. M., Lauder, I., and Aherne, W. A., Cell population kinetic profile of the mouse thymus, and the changes induced by prednisolone. Cell Tissue Kinet.12 (1979) 191–201.
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Kendall, M.D. Have we underestimated the importance of the thymus in man?. Experientia 40, 1181–1185 (1984). https://doi.org/10.1007/BF01946644
- thymic hormones
- thymic atrophy