, Volume 33, Issue 5, pp 649–650 | Cite as

Colchicine may interfere with the axonal transport of noradrenaline in the central noradrenergic neurons

  • M. Sorimachi
  • O. Hino
  • K. Tsunekawa


The administration of colchicine (50 μg) into the lateral ventricles induced the marked accumulation of noradrenaline in the locus coeruleus of rat. Lumicolchicine administration or stress loading failed to alter the noradrenaline levels, thus suggesting that this accumulation is related to the blockade of axonal flow in the central noradrenergic neurons.


Noradrenaline Colchicine Lateral Ventricle Locus Coeruleus Axonal Transport 
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Copyright information

© Birkhäuser-Verlag 1977

Authors and Affiliations

  • M. Sorimachi
    • 1
  • O. Hino
    • 1
  • K. Tsunekawa
    • 1
  1. 1.Department of PhysiologyEhime University Medical SchoolEhimeJapan

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