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Experientia

, Volume 33, Issue 5, pp 649–650 | Cite as

Colchicine may interfere with the axonal transport of noradrenaline in the central noradrenergic neurons

  • M. Sorimachi
  • O. Hino
  • K. Tsunekawa
Specialia

Summary

The administration of colchicine (50 μg) into the lateral ventricles induced the marked accumulation of noradrenaline in the locus coeruleus of rat. Lumicolchicine administration or stress loading failed to alter the noradrenaline levels, thus suggesting that this accumulation is related to the blockade of axonal flow in the central noradrenergic neurons.

Keywords

Noradrenaline Colchicine Lateral Ventricle Locus Coeruleus Axonal Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser-Verlag 1977

Authors and Affiliations

  • M. Sorimachi
    • 1
  • O. Hino
    • 1
  • K. Tsunekawa
    • 1
  1. 1.Department of PhysiologyEhime University Medical SchoolEhimeJapan

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