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Colchicine may interfere with the axonal transport of noradrenaline in the central noradrenergic neurons

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Summary

The administration of colchicine (50 μg) into the lateral ventricles induced the marked accumulation of noradrenaline in the locus coeruleus of rat. Lumicolchicine administration or stress loading failed to alter the noradrenaline levels, thus suggesting that this accumulation is related to the blockade of axonal flow in the central noradrenergic neurons.

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Author notes

  1. O. Hino & K. Tsunekawa

    Present address: Department of Surgery, Ehime University Medical School, Ehime, Japan

Authors and Affiliations

  1. Department of Physiology, Ehime University Medical School, Ehime, Japan

    M. Sorimachi, O. Hino & K. Tsunekawa

Authors
  1. M. Sorimachi
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  2. O. Hino
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  3. K. Tsunekawa
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Additional information

Acknowledgment. Authors thank Drs Y. Kakimoto and M. Miyake for their advice on the assay of catecholamines.

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Sorimachi, M., Hino, O. & Tsunekawa, K. Colchicine may interfere with the axonal transport of noradrenaline in the central noradrenergic neurons. Experientia 33, 649–650 (1977). https://doi.org/10.1007/BF01946553

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  • DOI: https://doi.org/10.1007/BF01946553

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