Summary
The levels of hepatic threonine dehydratase and tryptophan pyrrolase are elevated in 5% tyrosine-fed rats, and these increases are dependent on the dietary tyrosine level. Experiments with RNA and protein synthesis inhibitors indicate that the appearance of these new enzyme activities are dependet on concomitant new protein synthesis and the inducer operates at a transcriptional level.
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References
S. Q. Alam, R. N. Becker, W. P. Stucki, Q. R. Rogers and A. E. Harper, J. Nutr.89, 91 (1966).
S. Q. Alam, Q. R. Rogers and A. E. Harper, J. Nutr.89, 97 (1966).
C. Godin, J. Nutr.92, 503 (1967).
F. T. Kenney and R. M. Flora, J. biol. Chem.236, 2699 (1961).
W. E. Knox, M. N. D. Goswami and R. D. L. Hynch, Ann. N. Y. Acad. Sci.111, 212 (1963).
M. Keichiro, T. Masami and N. Kiyohi,J. Nutr.105, 439 (1975).
K. Datta and J. J. Ghosh, J. nutr., in press (1977).
D. A. Benton, A. E. Harper, H. E. Spivey and C. A. Elvehjem, Archs. Biochem. Biophys.60, 156 (1956).
R. H. Bottomley, H. C. Pitot, V. R. Porter and H. P. Morris, Cancer Res.,23, 400 (1963).
W. E. Knox, Meth. Enzym.2, 242 (1955).
O. H. Lowry, N. J. Rosenbrough, A. L. Farr and R. J. Randall, J. biol. Chem.193, 263 (1961).
G. M. Tomkins, E. B. Thomson, T. Hayashi, D. Gelherter, D. Granner and B. Peterkofsky, Cold Spring Harb. Symp. quant. Biol.31, 309 (1966).
G. M. Tomkins, B. B. Levinson, J. D. Baxter and L. Deth Lefsen, Nature New Biol.239, 9 (1972).
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Datta, K., Ghosh, J.J. Hepatic induction of threonine dehydratase and tryptophan pyrrolase in tyrotoxic rats. Experientia 33, 1018–1019 (1977). https://doi.org/10.1007/BF01945942
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DOI: https://doi.org/10.1007/BF01945942