Summary
Isotope effect studies on the metabolic dehydrogenation of Δ1-tetrahydrocannabinol in rats are described and its is shown that this process is confined to a very short period following i.v. administration. The implications of this finding are discussed.
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References
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The authors are grateful for generous fifts of3H-Δ1-THC from Dr S. Burstein (Worcester Foundation for Experimental Biology, Massachusetts), and of14C-Δ1-THC from the National Institute on Drug Abuse. The authors thank the staff of the Small Animal Unit, Wallaceville Research Centre for their cooperation, and the U.S. National Institute on Drug Abuse for their support.
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McCallum, N.K., Gugelmann, A., Brenninkmeijer, C.A.M. et al. Isotope effect studies on the dehydrogenation of Δ1-tetrahydrocannabinol in the rat. Experientia 33, 1012–1014 (1977). https://doi.org/10.1007/BF01945939
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DOI: https://doi.org/10.1007/BF01945939