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Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin

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Summary

In C57BL/6 mice a single oral dose of 2, 3, 7, 8-tetrachlorodibenzodioxin (LD50 126 μg/kg) results in loss of body weight and death with an enlarged fatty liver after ca. 21 days. A progressive necrotic centrilobular liver lesion is also seen.

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Authors and Affiliations

  1. MRC Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, SM 5 4EF, Carshalton, Surrey, England

    G. Jones & J. B. Greig

Authors
  1. G. Jones
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  2. J. B. Greig
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Jones, G., Greig, J.B. Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin. Experientia 31, 1315–1317 (1975). https://doi.org/10.1007/BF01945801

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  • DOI: https://doi.org/10.1007/BF01945801

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