Summary
The highest lactate dehydrogenase (LDH) activity was found in thalamus, statistically significantly less in cerebral and cerebellar cortex and the lowest in pons. LDH1 and LDH4+5 represented 58% and 23% of the total activity in cerebral cortex, 54% and 20% in thalamus, 42% and 4% in cerebellar cortex and 55% and 7% in pons, respectively.
Similar content being viewed by others
References
R. V. Živković, B. B. Mršulja andB. M. Djuričić, Experientia31, 404 (1975).
D. M. Dawson, T. L. Goodfriend andN. O. Kaplan, Science143, 929 (1964).
E. M. Tarmy andN. O. Kaplan, J. biol. Chem.243, 2587 (1968).
J. H. Wilkinson,Isoenzymes (E. & F. N. Spon Ltd., London 1965).
H. U. Bergmeyer, E. Bernt andB. Hess, inMethods of Enzymatic Analysis (Ed.H. U. Bergmeyer; Academic Press, New York and London 1963), p. 742.
D. T. Plummer, B. A. Elliot, K. B. Cooke andJ. H. Wilkinson, Biochem. J.87, 416 (1963).
S. B. Rosalki andJ. H. Wilkinson, Nature, Lond.188, 1110 (1960).
E. F. Hartree, Analyt. Biochem.48, 422 (1972).
P. C. MacDonnel andO. Greengard, Arch. Biochem. Biophys.163, 644 (1974).
J. Nagata, K. Mikushika andY. Tsukada, J. Neurochem.22, 493 (1974).
T. H. Wieland, G. Pfleiderer, J. Haupt andW. Wörner, Biochem. Z.332, 1 (1959).
A. Norstrom, G. Eggersten, H. Freden andS. Enestrom, Exp. Neurol.37, 502 (1972).
T. Kato andO. H. Lowry, J. Neurochem.20, 151 (1973).
S. Futterman andJ. H. Kinoshita, J. biol. Chem.234, 3174 (1959).
H. Pasantes-Morales, J. Kletki, P. F. Urban andP. Mandel, J. Neurochem.19, 1183 (1972).
F. C. Kaufman, J. Neurochem.19, 1 (1972).
D. Eby, S. Saltke andA. Lukten, Biochim. biophys. Acta327, 227 (1973).
Author information
Authors and Affiliations
Additional information
Authors wish to express their gratitude toT. C. Detwiler (Downstate Medical Center, New York) for his helpful criticism during preparation of manuscript.
Rights and permissions
About this article
Cite this article
Živković, R.V., Djuričić, B.M. Regional distribution of lactate dehydrogenase isoenzymes in adult rat brain. Experientia 31, 1258–1260 (1975). https://doi.org/10.1007/BF01945765
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01945765