Summary
Advances in molecular biology have allowed for the identification of potential vaccine candidates against several parasitic diseases. Antigens from various life stages ofPlasmodium andSchistosoma species and filarial worms have been cloned, sequenced and tested as vaccines. Results to date in animal models have been promising. Modest levels of protection against experimental human malaria have been obtained using both sporozoite and blood-stage antigens. However, a greater understanding of the mechanisms which lead to immunity against parasites is required before effective vaccines can be developed.
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Akiyama, T., Ushijima, N., Anan, S., Nonaka, S., Yoshida, H., and Flores, G. E. Z., Immunological studies of onchocerciasis in Guatemala. I. Immunoglobulin levels in Guatemalan onchocerciasis. J. Dermat.8 (1981) 43–46.
Ballou, R. W., Hoffman, S. L., Sherwood, J. A., Hollingdale, M. R., Neva, F. A., Hockmeyer, W. T., Gordon, D. M., Schneider, I., Wirtz, R. A., Young, J. F., Wasserman, G. F., Reeve, P., Diggs, C. L., and Chulay, J. D., Safety and efficacy of a recombinant DNAPlasmodium falciparum sporozoite vaccine. Lancet1 (1987) 1277–1281.
Ballou, W. R., Rothbard, J., Wirtz, R. A., Gordon, D. M., Williams, J. S., Gore, R. W., Schneider, I., Hollingdale, M. R., Beaudoin, R. L., Maloy, W. L., Miller, L. H., and Hockmeyer, W. T., Immunogenicity of synthetic peptides from circumsporozoite protein ofPlasmodium falciparum. Science228 (1985) 996–999.
Balloul, J. M., Sondermeyer, P., Dreyer, D., Capron, M., Grzych, J. M., Pierce, R. J., Carvallo, D., Lecocq, J. P., and Capron, A., Molecular cloning of a protective antigen of schistosomes. Nature326 (1987) 149–153.
Butterworth, A. E., and Hagan, P., Immunity in human schistosomiasis. Parasit. Today3 (1987) 11–16.
Butterworth, A. E., Sturrock, R. F., Houba, V., Mahmoud, A. A. F., Sher, A., and Rees, P. H., Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature256 (1975) 727–729.
Byars, N. E., and Allison, A. C., Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity. Vaccine5 (1987) 223–228.
Canlas, M., Wadee, A., Lamontagne, L., and Piessens, W. F., A monoclonal antibody to surface antigens on microfilariae ofBrugia malayi reduces microfilaremia in infected jirds. Am. J. trop. Med. Hyg.33 (1984) 420–426.
Capron, M., and Capron, A., Rats, mice and men-models for immune effector mechanisms against schistosomiasis. Parasit. Today2 (1986) 69–75.
Cochrane, A. H., Nussenzweig, R. S., and Nardin, E. H., Immunization against sporozoites, in: Malaria in Man and Experimental Animals, pp. 163–202. Ed. J. P. Krier. Academic Press, Inc., New York 1980.
Dame, J. B., Williams, J. L., McCutchan, T. F., Weber, J. L., Wirtz, R. A., Hockmeyer, W. T., Maloy, W. L., Haynes, J. D., Schneider, I., Roberts, D., Sanders, G. S., Reddy, E. P., Diggs, C. L., and Miller, L. H., Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasitePlasmodium falciparum. Science225 (1984) 593–599.
Freedman, D. O., Nutman, T. B., and Ottesen, E. A., Protective immunity in bancroftian filariasis. Selective recognition of a 43-kDa larval stage antigen by infection-free individuals in an endemic area. J. clin. Invest.83 (1989) 14–22.
Good, M. F., Kumar, S., and Miller, L. H., The real difficulties for malaria sporozoite vaccine development: nonresponsiveness and antigenic variation. Immun. Today9 (1988) 351–355.
Good, M. F., Maloy, W. L., Lunde, M. N., Margalit, H., Cornette, J. L., Smith, G. L., Moss, B., Miller, L. H., and Berzofsky, J. A., Construction of synthetic immunogens: use of new T-helper epitope on malaria circumsporozoite protein. Science235 (1987) 1059–1062.
Good, M. F., Pombo, D., Quakyi, I. A., Riley, E. M., Houghten, R. A., Menon, A., Alling, D. W., Berzofsky, J. A., and Miller, L. H., Human T-cell recognition of the circumsporozoite protein ofPlasmodium falciparum; immunodominant T-cell domains map to the polymorphic regions of the molecule. Proc. natl Acad. Sci. USA85 (1988) 1199–1204.
Greene, B. M., Gbakima, A. A., Albiez, E. J., and Taylor, H. R., Humoral and cellular immune responses toOnchocerca volvulus infection in humans. Rev. infect. Dis.7 (1985) 789–795.
Greene, B. M., Taylor, H. R., and Aikawa, M., Cellular killing of microfilariae ofOnchocerca volvulus: eosinophil and neotophil-mediated immune serum-dependent destruction. J. immun.127 (1981) 1611–1618.
Hagan, P., Wilkins, H. A., Blumenthal, U. J., Hayes, R. J., and Greenwood, B. M., Eosinophilia and resistance toSchistosoma haematobium in man. Parasite Immun.7 (1985) 625–632.
Hayashi, Y., Noda, K., Shirasaka, A., Nogami, S., and Nakamura, M., Vaccination of BALB/c mice againstBrugia malayi andB. pahangi with larvae attenuated by gamma irradiation. Jap. J. exp. Med.54 (1984) 177–181.
Herrington, D. A., Clyde, D. F., Lasonsky, G., Cortesia, M., Murphy, J. R., Davis, J., Baqar, S., Felix, A. M., Heimer, E. P., Gillessen, D., Nardin, E., Nussenzweig, R. S., Nussenzweig, V., Hollingdale, M. R., and Levine, M. M., Safety and immunogenicity in man of a synthetic peptide malaria vaccine againstPlasmodium falciparum sporozoite. Nature328 (1987) 257–259.
Hussain, R., Grögl, M., and Ottesen, E. A., IgG antibody subclasses in human filariasis: differential subclass recognition of parasite antigens correlates with different clinical manifestations of infection. J. Immun.139 (1987) 2794–2798.
Kazura, J. W., Cicirello, H., and Forsyth, K. P., Differential recognition of a protective filarial antigen by antibodies from humans with bancroftian filariasis. J. clin. Invest.77 (1986) 1985–1992.
Kazura, J. W., Cicerello, H., and McCall, J. W., Induction of protection againstBrugia malayi in jirds by microfilarial antigens. J. Immun.136 (1986) 1422–1426.
Kazura, J. W., and Davis, R. S., SolubleBrugia malayi microfilarial antigens protect mice against challenge by an antibody-dependent mechanism. J. Immun.128 (1982) 1792–1796.
Khalife, J., Capron, M., Capron, A., Grzych, J.-M., Butterworth, A. E., Dunne, D. W., and Ouma, J. H., Immunity in human schistosomiasis masoni: regulation of protective immune mechanisms by IgM blocking antibodies. J. exp. Med.164 (1986) 1626–1640.
Lal, R. B., and Ottesen, E. A., Characterization of the stage-specific antigens of infective larvae of the filarial parasiteBrugia malayi. J. Immun.140 (1988) 2032–2038.
Lowell, G. H., Smith, L. F., Seid, R. C., and Zollinger, W. D., Peptides bound to proteosomes via hydrophobic feet become highly immunogenic without adjuvants. J. exp. Med.167 (1988) 658–663.
McCarthy, V., and Clyde, D.,Plasmodium vivax: correlation of circumsporozoite precipitation (CSP) reaction with sporozoite-induced protective immunity in man. Exp. Parasit.41 (1977) 167–171.
Nilsen, T. W., Maroney, P. A., Goodwin, R. G., Perrine, K. G., Denker, J. A., Nanduri, J., and Kazura, J. W., Cloning and characterization of a potentially productive antigen in lymphatic filariasis. Proc. natl Acad. Sci. USA85 (1988) 3604–3607.
Oothuman, P., Denham, D. A., McGreevy, P. B., Nelson, G. S., and Rogers, R., Successful vaccination of cats againstBrugia pahangi with larvae attenuated by irradiation with 10 krad cobalt 60. Parasite Immun.1 (1979) 209–215.
Otteson, E. A., Nera, F. A., Paranjape, R. S., Tripathy, S. P., Thisurengadam, K. V., and Beaven, M. A., Specific allergic sensitization to filarial antigens in tropical eosinophilia syndrome. Lancet1 (1989) 1158–1161.
Piessens, W. F., Partono, F., Hoffman, S. L., Ratiwayanto, S., Piessens, P. W., Palmieri, J. R., Koiman, I., Dennis, D. T., and Carney, W. P., Antigen-specific suppressor T lymphocytes in human lymphatic filariasis. N. Engl. J. Med.307 (1982) 144–148.
Playfair, J. H. L., Immunity to malaria. Br. med. Bull.38 (1982) 153–159.
Que, J. U., Cryz, S. J., Jr, Ballou, R., Fürer, E., Gross, M., Young, J., Wasserman, G. F., Loomis, L. A., and Sadoff, J. C., Effect of carrier selection on immunogenicity of protein conjugate vaccines againstPlasmodium falciparum circumsporozoites. Infect. Immun.56 (1988) 2645–2649.
Rudbach, J. A., Cantrell, J. L., and Ulrich, J. T., Molecularly engineered microbial immunostimulators. Proc. U.C.L.A. Symp. molec. cell. Biol.84 (1988) 443–454.
Sadoff, J. C., Ballou, W. R., Baron, L. S., Majarian, W. R., Brey, R. N., Hockmeyer, W. T., Young, J. F., Cryz, S. J., Ou, J., Lowell, G. H., and Chulay, J. D., OralSalmonella typhimurium vaccine expressing circumsporozoite protein protects against malaria. Science240 (1988) 336–338.
Schofield, L., Villaquiran, J., Ferreira, A., Schellekens, H., Nussenzweig, R., and Nussenzweig, V., τ-Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature330 (1987) 664–666.
Selkirk, M. E., Denham, D. A., Partono, F., Sutanto, I., and Maizels, R. M., Molecular characterization of antigens of lymphatic filarial parasites. Parasitology91 (1986) S15-S38.
Simpson, A. J. G., and Cioli, D., Progress toward a defined vaccine for schistosomiasis. Parasit. Today3 (1987) 26–28.
Steward, M. W., Sisley, B., Mackenzie, C. D., and El-Sheik, H. E., Circulating antigen-antibody complexes in oncherocerciasis. Clin. exp. Immun.48 (1982) 17–24.
Sturrock, R. F., Kimani, R., Cottrell, B. J., Butterworth, A. E., Seitz, H. M., Siongok, T. K., and Houba, V., Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment forSchistosoma mansoni. Trans. R. Soc. trop. Med. Hyg.77 (1983) 363–371.
Todd, C. W., Goodgame, R. W., and Colley, D. G., Immune responses during human schistosomiasis mansoni. V. Suppression of schistosome antigen-specific lymphocyte blastogenesis by adherent/phagocytic cells. J. Immun.122 (1979) 1440–1446.
von Lichtenberg, F., Conference on contended issues of immunity to schistosomes. Am. J. trop. Med. Hyg.34 (1985) 78–85.
Weiss, W. R., Sedegah, M., Benudoin, R. L., Miller, L. H., and Good, M. F., CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc. natl Acad. Sci. USA85 (1988) 573–576.
Wilkins, H. A., Goll, P. H., Marshall, T. F. de C., and Moore, P. J., Dynamics ofSchistosoma haematobium infection in a Gambian community. III. Acquisition and loss of infection. Trans. R. Soc. trop. Med. Hyg.78 (1984) 227–232.
Wong, M. M., Fredericks, H. J., and Ramachandran, C. P., Studies on immunization againstBrugia malayi infections in the Rhesus monkey. Bull. WHO40 (1969) 493–501.
World Health Organization, Protective immunity and vaccination in onchocerciasis and lymphatic filariasis: Report of the thirteenth meeting of the scientific working group on filariasis. WHO Document TDR/FIL/SWG (13)/87.3, Geneva, 1987.
Yoshida, N., Nussenzweig, R. S., Potocnjak, P., Aikawa, M., and Nussenzweig, V., Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasites. Science207 (1980) 71–73.
Zavala, F., Masuda, A., Graves, P. M., Nussenzweig, V., and Nussenzweig, R. S., Ubiquity of the repetitive epitope of the CS protein in different isolates of human malaria parasites. J. Immun.135 (1985) 2790–2793.
Zavala, F., Tam, J. P., Hollingdale, M. R., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S., and Nussenzweig, V., Rationale for development of a synthetic vaccine againstPlasmodium falciparum malaria. Science228 (1985) 1436–1440.
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Cryz, S.J. Molecular parasitology: Progress towards the development of vaccines for malaria, filariasis, and schistosomiasis. Experientia 47, 146–151 (1991). https://doi.org/10.1007/BF01945415
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DOI: https://doi.org/10.1007/BF01945415