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The effects of phenoxybenzamine on the aortic pressure-diameter relationship in dogs

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Summary

The normalized diameter (D/D13.3 where D13.3 equals D at 13.3 kPa under control conditions) was measured at selected pressure levels under different hemodynamic conditions. Hemorrhage caused the normalized diameter to decrease (−3.3%) when compared to control values at a given pressure. Volume expansion anda-blockade with phenoxybenzamine caused D/D13.3 to increase (+3.3% and +8.5% respectively).

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Authors and Affiliations

  1. Department of Physiology, The Ohio State University, 1645 Neil Avenue, 43210, Columbus, OH, USA

    D. N. Stone & J. -P. L. Dujardin

Authors
  1. D. N. Stone
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  2. J. -P. L. Dujardin
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Additional information

This work was supported in part by PHS grant HL-23239 and a grant from the Central Ohio Heart Chapter of the American Heart Association. To whom reprint request should be addressed.

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Stone, D.N., Dujardin, J.P.L. The effects of phenoxybenzamine on the aortic pressure-diameter relationship in dogs. Experientia 38, 257–258 (1982). https://doi.org/10.1007/BF01945099

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