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Cytoprotection-organoprotection by somatostatin: gastric and hepatic lesions

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Summary

In rats, the hemorrhagic gastric erosions produced by ethanol, and the fatal hemorrhagic hepatic recrosis induced by phalloidin, were significanlty reduced by regular somatostatin, but not by derivatives devoid of-SH containing cysteines. These effects of the hormone were abolished in animals which received, in a dditiion, the sulfhydryl blocker nethylmaleimide before the toxic chemicals. Thus, somatostain exhibits organoprotection dependent on endogenous sulfhydryls.

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References

  1. A. Robert, Gastroenterology77, 761 (1979).

    Article  CAS  PubMed  Google Scholar 

  2. A. Robert, J. E. Nezamis, C. Lancaster and A. J. Hanchar, Gastoenterology77, 433 (1979).

    Article  CAS  Google Scholar 

  3. T. A. Miller and E. D. Jacobson, Gut20 75 (1979).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. E. Kivilaakso and W. Silen, N. Engl. J. Med.301, 364 (1979).

    Article  CAS  PubMed  Google Scholar 

  5. M. I. Grossman, Gastroenterology77, 593 (1979).

    Article  CAS  PubMed  Google Scholar 

  6. P. H. Guth, D. Aures and G. Paulsen, Gastroenterology76, 88 (1979).

    Article  CAS  PubMed  Google Scholar 

  7. S. Szabo, J. S. Trier and P. W. Frankel, Science214, 200 (1981).

    Article  CAS  PubMed  Google Scholar 

  8. P. Mattes, S. Raptis and T. Heil, Horm. Metab. Res.7, 508 (1975).

    Article  CAS  PubMed  Google Scholar 

  9. U. Schwedes, K. H. Usadel and S. Szabo, Eur. J. Pharmac.44, 195 (1977).

    Article  CAS  Google Scholar 

  10. P. O. Schwille, F. Putz, R. Thun, W. Schellerer, G. Draxler and G. Lang, Acta hepato-gastroent24 259 (1977).

    CAS  Google Scholar 

  11. L. Kayasseh, K. Gyr, U. Keller, G. A. Stalder and U. Keller, Lancet1, 844 (1980).

    Article  CAS  PubMed  Google Scholar 

  12. K. H. Usadel, U. Leuschner and K. K. Überla, N. Engl. J. Med.303, 999 (1980).

    Article  CAS  PubMed  Google Scholar 

  13. U. Schwedes, P. H. Althoff, I. Klempa, U. Leuschner, L. Mothes, S. Raptis, J. Wdowinski and K. H. Usadel, Horm. Metab. Res.11, 647 (1979).

    Article  Google Scholar 

  14. S. Raptis, W. Schlegel, E. Lehmann, H. C. Dollinger and C. H. Zoupas, Metabolism27, 1321 (1978).

    Article  CAS  PubMed  Google Scholar 

  15. J. M. Wdowinski, U. Schwedes, K. H. Usadel, W. Siede and K. Schoffing, Proc. 5th int. Congr. Endocr. Melbourne, Endocrinology in press (1980).

  16. J. M. Wdowinski, U. Schwedes, H. Faulstich, H. Danzygier, U. Leuschner and K. H. Usadel, Res. exp. Med.178, 155 (1981).

    Article  CAS  Google Scholar 

  17. U. Schwedes, S. Szabo and K. H. Usadel, Metabolism27, suppl. 1, 1377 (1978).

    Article  CAS  PubMed  Google Scholar 

  18. U. Schwedes, J. Wdowinski, P. H. Althoff and K. H. Usadel, Acta endocr., Copenh., suppl234, 142 (1980).

    Google Scholar 

  19. T. Wieland and H. Faulstich, Frontiers in Bioorganic Chemistry and Molecular Biology. Elsevier/North Holland Biomedical Press, New York 1979.

    Google Scholar 

  20. B. Saffouri, G. C. Wier, K. N. Bitar and G. M. Makhlouf, Am. J. Physiol.238, G495 (1980).

    CAS  PubMed  Google Scholar 

  21. S. Szabo and S. Reichlin, Gastroenterology76, 1257 (1979).

    Google Scholar 

  22. S. Szabo and S. Reichlin, Endocrinology109, 2255 (1981).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, 02115, Boston, MA, USA

    S. Szabo & K. H. Usadel

  2. Zentrum der Inneren Medizin, Klinikum der J. W. Goethe Univesität, D-6000, Frankfurt, Germany

    S. Szabo & K. H. Usadel

Authors
  1. S. Szabo
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  2. K. H. Usadel
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Acknowledgment. These studies were supported in part by a grant from Serono.

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Szabo, S., Usadel, K.H. Cytoprotection-organoprotection by somatostatin: gastric and hepatic lesions. Experientia 38, 254–256 (1982). https://doi.org/10.1007/BF01945097

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