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Zur Biosynthese von Biopterin in Säugetieren

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Summary

Biosynthesis of biopterin in mice and rats was studied. After vascular injection of14C-GTP (U) in mice and rats, radioactive biopterin was isolated from the urine. The specific radioactivity of 6-carboxypterin obtained by oxidation of biopterin was proved to be 7/9 that of biopterin. The result definitely shows that biopterin is biosynthesized from GTP in mice and rats, and the sidechain of biopterin is derived directly from the ribose moiety of GTP.

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Authors and Affiliations

  1. Chemisches Institut der Gakushuin-Universität, Toshima-ku, 171, Tokyo, Japan

    K. Sugiura & M. Goto

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  1. K. Sugiura
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  2. M. Goto
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Sugiura, K., Goto, M. Zur Biosynthese von Biopterin in Säugetieren. Experientia 29, 1481–1482 (1973). https://doi.org/10.1007/BF01943868

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  • DOI: https://doi.org/10.1007/BF01943868

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