Skip to main content
SpringerLink
Log in

The effect of halothane on in vitro human neutrophil chemotaxis

  • Published:
Experientia Aims and scope Submit manuscript

Summary

Increasing concentrations of halothane were shown to sequentially inhibit directed (chemotactic) and random movement of human peripheral blood neutrophils. No influence on neutrophil movement was apparent at clinically important concentrations, halothane may effect neutrophil microtubule and actomyosin microfilament systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. E. Malawista and K. G. Bensch, Science156, 521 (1967).

    Article  CAS  PubMed  Google Scholar 

  2. A. C. Allison, Antibiot. Chemother.19, 191 (1974).

    Article  CAS  PubMed  Google Scholar 

  3. R. D. Berlin, Ann. N. Y. Acad. Sci.253, 445 (1975).

    Article  CAS  PubMed  Google Scholar 

  4. J. B. Olmstead and G. G. Borisy, A. Rev. Biochem.42, 507 (1973).

    Article  Google Scholar 

  5. N. Senda, N. Shibata, N. Tatsumi, K. Kondo and K. Hamada, Biochim. Biophys. Acta181, 191 (1969).

    Article  CAS  PubMed  Google Scholar 

  6. A. C. Allison, P. Davies, S. de Petris, Nature New Biol.232, 153 (1971).

    Article  CAS  PubMed  Google Scholar 

  7. T. P. Stossel, T. D. Pollard, J. Biol. Chem.248, 8288 (1973).

    Article  CAS  PubMed  Google Scholar 

  8. E. P. Reaven, S. G. Axline, J. Cell Biol.59, 12 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. V. Bandmann, L. Rydgren and B. Norberg, Exp. Cell Res.88, 63 (1974).

    Article  CAS  PubMed  Google Scholar 

  10. S. E. Malawista, Arthritis Rheum.8, 752 (1965).

    Article  CAS  PubMed  Google Scholar 

  11. J. E. Z. Caner, Arthritis Rheum.8, 757 (1965).

    Article  CAS  PubMed  Google Scholar 

  12. J. F. Borel, Experientia29, 676 (1973).

    Article  CAS  PubMed  Google Scholar 

  13. V. Bandmann, B. Norberg and G. Simmingskold, Scand. J. Haemat.15, 81 (1975).

    Article  CAS  PubMed  Google Scholar 

  14. L. Wilson, Life Sci.17, 303 (1975).

    Article  CAS  PubMed  Google Scholar 

  15. A. C. Allison and J. F. Nunn, Lancet2, 1326 (1968).

    Article  CAS  PubMed  Google Scholar 

  16. A. C. Allison, G. H. Hulands, J. F. Nunn, J. A. Kitching and A. C. MacDonald, J. Cell Sci.7, 483 (1970).

    Article  CAS  PubMed  Google Scholar 

  17. J. F. Nunn, J. A. Sharp, K. L. Kimball, Nature226, 85 (1970).

    Article  CAS  PubMed  Google Scholar 

  18. B. F. Cullen, Anesth. Analg.53, 531 (1974).

    Article  CAS  PubMed  Google Scholar 

  19. S. Boyden, J. exp. Med.115, 453 (1962).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. H. V. Keller and E. Sorkin, Int. Archs Allergy appl. Immun.31, 575 (1967).

    Article  CAS  Google Scholar 

  21. R. G. Merin, T. Kumazawa and C. R. Honig, in: Recent Advances in Studies on Cardiac Structure and Metabolism, vol. 5, 405 (1975).

Download references

Author information

Author notes

  1. J. J. Schlesinger

    Present address: Infectious Disease Service and Department of Medicine, Madigan Army Medical Center, 98431, Tacoma, Washington, USA

Authors and Affiliations

  1. Infectious Disease Service and Department of Medicine, Madigan Army Medical Center, 98431, Tacoma, Washington, USA

    A. L. Ross

Authors
  1. J. J. Schlesinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. L. Ross
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgments. We thank Mr Lous Matej for his skillful technical assistance.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schlesinger, J.J., Ross, A.L. The effect of halothane on in vitro human neutrophil chemotaxis. Experientia 33, 69–70 (1977). https://doi.org/10.1007/BF01936760

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01936760

Keywords

Search

Navigation