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Folic acid and the inhibition of brain L-glutamic decarboxylase

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Summary

Folic acid competitively inhibited brainl-glutamic decarboxylase (K i=1.62×10−3 M). This inhibition could possibly be associated with epilepsy.

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Authors and Affiliations

  1. Laboratory of Neurochemistry, Clinical Research Institute of Montreal, 110 Pine Avenue West, H2W 1R7, Montreal, Quebec, Canada

    G. Tunnicliff & T. T. Ngo

Authors
  1. G. Tunnicliff
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  2. T. T. Ngo
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This work was supported by the United Parkinson Foundation.

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Tunnicliff, G., Ngo, T.T. Folic acid and the inhibition of brain L-glutamic decarboxylase. Experientia 33, 67–68 (1977). https://doi.org/10.1007/BF01936759

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  • DOI: https://doi.org/10.1007/BF01936759

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