Summary
The topographic distribution of (3H)-spiroperidol binding sites (corresponding to dopamine receptors likely) was studied in rabbit splenic artery by the use of a histoautoradiographic technique. (3H)-spiroperidol was localized preferentially at the level of smooth muscle cells of the media as well as in close relation with cellular membrane of endothelial cells.
The findings of a constant distribution of (3H)-spiroperidol binding sites within the medial layer of the splenic artery led us to hypothesize that these receptors mediate the relaxation of the splenic artery determined by dopamine infusion.
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Amenta, F., Cantagalli, A., Cavallotti, C. et al. (3H)-spiroperidol binding sites in the rabbit splenic artery. Basic Res Cardiol 79, 80–85 (1984). https://doi.org/10.1007/BF01935810
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DOI: https://doi.org/10.1007/BF01935810