, Volume 33, Issue 12, pp 1554–1555 | Cite as

New tigliane and daphnane derivatives fromPimelea prostrata andPimelea simplex

  • S. Zayed
  • A. Hafez
  • W. Adolf
  • E. Hecker
Specialia Pimelea Simplex


From the methanol extract ofPimelea prostrata, prostratin (I) and 2 autoxidation products have been isolated. They are tigliane derivatives and relatively nonirritant on the mouse ear. The irritant pimelea factor P5 (IIa) also with a tigliane skeleton and related to mancinellin (IIb), as wellas the irritant diterpene ester pimelea factor P1 (IIa, simplexin) with daphnane skeleton, were found to be present in bothP. prostrata andP. simplex. Further the irritant homologue of simplexin, pimela factorIIIb was detected inP. prostrata. Some biogenetic consequences of these findings are discussed.


Methanol Ester Methanol Extract Diterpene Autoxidation Product 
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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • S. Zayed
    • 1
  • A. Hafez
    • 1
  • W. Adolf
    • 1
  • E. Hecker
    • 1
  1. 1.Institut für BiochemieDeutsches KrebsforschungszentrumHeidelberg 1(Federal Republic of Germany, BRD)

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