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Renal effects of the prostaglandins A1 and E2 in hydrated and hydropenic dogs

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Zusammenfassung

PGA1 und PGE2 erhöhen die Nierendurchblutung sowohl im Zustand des Wassermangels als auch der Überwässerung, während PGE2 nicht aber PGA1 unabhängig vom Flüssigkeitsgleichgewicht die renale Wasser- und Elektrolytexkretion steigert. Beide PGs erhöhen die Ausscheidung von cAMP. Sie wirken ADH-ähnlich während einer Wasserdiurese und nicht antagonsitisch gegen ADH während der Antidiurese.

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Literatur

  1. G. Fülgraff andG. Brandenbusch, Pflügers Arch.349, 9 (1974).

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  2. G. Fülgraff, G. Brandenbusch andK. Heintze, Prostaglandins, in press.

  3. G. Fülgraff andA. Meiforth, Pflügers Arch.330, 243 (1971).

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  5. The prostaglandins were a gift from the Upjohn Company.

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Authors and Affiliations

  1. Zentrum der Pharmakologie, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-6, Frankfurt am Main 70, Germany

    G. Fülgraff, G. Brandenbusch, K. Heintze & A. Meiforth

  2. Abteilung Pharmakologie der Technischen Hochschule Aachen, D-51, Aachen, Germany

    G. Fülgraff, G. Brandenbusch, K. Heintze & A. Meiforth

Authors
  1. G. Fülgraff
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  2. G. Brandenbusch
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  3. K. Heintze
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  4. A. Meiforth
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Additional information

This work was supported by the Deutsche Forschungsgemeinschaft.

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Fülgraff, G., Brandenbusch, G., Heintze, K. et al. Renal effects of the prostaglandins A1 and E2 in hydrated and hydropenic dogs. Experientia 31, 65–66 (1975). https://doi.org/10.1007/BF01924682

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  • DOI: https://doi.org/10.1007/BF01924682

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