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Muscarinic involvement in vascular and adrenal medullary responses to splanchnic nerve stimulation in conscious calves

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Abstract

Stimulation of the peripheral end of the right splanchnic nerve (4 Hz for 10 min) in the presence of hexamethonium caused a small but significant rise in mean aortic blood pressure which was subsequently abolished by atropine. There were also small but significant increases in the outputs of catecholamines, [Met5]-enkephalins and corticotrophin releasing factor (CRF) from the right adrenal gland. The catecholamine response was roughly halved after atropine while the outputs of enkephalins and CRF were unaffected. It is concluded that splanchnic sympathetic postganglionic neurones supplying the vasculature are completely blocked by cholinergic blockade whereas adrenal medullary responses persist in an attenuated form.

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Authors and Affiliations

  1. Laboratory of Cellular and Developmental Physiology, Institute for Molecular Medicine, University of Oxford, Headley Way, OX3 9 DS, Oxford, England, UK

    C. T. Jones

  2. Physiological Laboratory, University of Cambridge, Downing Street, CB2 3EG, Cambridge, England, UK

    A. V. Edwards

Authors
  1. C. T. Jones
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  2. A. V. Edwards
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Jones, C.T., Edwards, A.V. Muscarinic involvement in vascular and adrenal medullary responses to splanchnic nerve stimulation in conscious calves. Experientia 50, 931–935 (1994). https://doi.org/10.1007/BF01923481

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  • DOI: https://doi.org/10.1007/BF01923481

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