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Colchicine inhibition of ADH effect on frog skin permeability

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Summary

ADH and AMPc enhance both thiourea unidirectional fluxes in frog skin. This effect is completely abolished by colchicine pretreatment. The ADH increase of thiourea discharge with or without colchicine led us to suppose that colchicine does not directly affect ADH action on outer membrane permeability, but exerts its effects on a site which is limiting for the ADH action on transepithelial permeability.

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Authors and Affiliations

  1. Institute of General Physiology, University of Bari, via Amendola 165A, I-70126, Bari, (Italy)

    M. Svelto & C. Lippe

Authors
  1. M. Svelto
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  2. C. Lippe
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Additional information

The present work has been supported by C.N.R., Rome.

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Svelto, M., Lippe, C. Colchicine inhibition of ADH effect on frog skin permeability. Experientia 34, 360–361 (1978). https://doi.org/10.1007/BF01923035

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  • DOI: https://doi.org/10.1007/BF01923035

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