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Erythrocyte catechol-O-methyltransferase and plasma dopamine-β-hydroxylase in human umbilical cord blood

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Summary

Plasma dopamine-β-hydroxylase enzymatic activity and immunoreactive protein levels in human umbilical cord blood are only about 2% as great as values in the blood of older subjects. Erythrocyte catechol-O-methyltransferase activity levels in umbilical cord blood are very similar to those in the blood of adult subjects.

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References

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Author notes

  1. R. M. Weinshilboum, J. Dunnette & F. Raymond

    Present address: Clinical Pharmacology Unit, Departments of Pharmacology and Internal Medicine, Mayo Foundation, 55901, Rochester, Minnesota, USA

  2. F. Kleinberg

    Present address: Department of Pediatrics, Mayo Clinic, 55901, Rochester, Minnesota, USA

Authors and Affiliations

  1. Clinical Pharmacology Unit, Departments of Pharmacology and Internal Medicine, Mayo Foundation, 55901, Rochester, Minnesota, USA

    F. Kleinberg

  2. Department of Pediatrics, Mayo Foundation, 55901, Rochester, Minnesota, USA

    R. M. Weinshilboum, J. Dunnette, F. Raymond & F. Kleinberg

  3. Department of Pediatrics, Mayo Clinic, 55901, Rochester, Minnesota, USA

    R. M. Weinshilboum, J. Dunnette & F. Raymond

Authors
  1. R. M. Weinshilboum
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  2. J. Dunnette
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  3. F. Raymond
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  4. F. Kleinberg
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Additional information

This work was supported in part by NIH grants NS 11014 and HL 17487-1. Dr Weinshilboum is an Established Investigator of the American Heart Association. We thank Luanne Wussow and the physicians and nurses of the Department of Obstetrics and Gynecology of the Mayo Clinic for their assitance with these studies.

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Weinshilboum, R.M., Dunnette, J., Raymond, F. et al. Erythrocyte catechol-O-methyltransferase and plasma dopamine-β-hydroxylase in human umbilical cord blood. Experientia 34, 310–311 (1978). https://doi.org/10.1007/BF01923004

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  • DOI: https://doi.org/10.1007/BF01923004

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