Abstract
Ondansetron (0.08, 0.15 or 0.3 mg/kg) injected s.c., every 12h with the fourth dose given 0.5 h before experiments, dose-dependently lessened gastric glandular mucosal ulceration produced by cold-restraint stress for 2h. When given intracerebrally (i.c.) (0.1, 0.5 or 1μg), using the same treatment regimen, infusion of ondansetron 1 μg into the nucleus amygdaloideus centralis decreased stress-evoked ulcers; in contrast, injection of the same dose into the nucleus accumbens intensified these lesions. The associated stress-induced stomach wall mast cell degranulation was unaffected by all s.c. or i.c. doses of ondansetron. Pretreatment with disodium cromoglycate i.p. alone, or concurrently with ondansetron s.c., prevented not only ulceration but also mast cell degranulation. 5-Hydroxytryptamine3 receptor antagonism appears to inhibit stress-evoked ulcers mainly by blocking the peripheral effects of the amine after its release from the gastric mucosal mast cells.
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Brodie, B. B., and Shore, P. A., Ann. N.Y. Acad. Sci.66 (1957) 631.
Cubeddu, L. X., Hoffmann, I. S., Fuenmayor, N. T., and Finn, A. L., New Engl. J. Med.322 (1990) 810.
Bendift, E. P., Ann. N.Y. Acad. Sci.103 (1963) 204.
Ogle, C. W., Hui, S-C.G., Qiu, B. S., and Li, K. M., Acta physiol. hung.80 (1992) 181.
Qiu, B. S., Cho, C. H., and Ogle, C. W., Experientia48 (1992) 389.
Costall, B., Hui, S.-C.G., and Nayylor, R. J., Neuropharmacology19 (1980) 1039.
De Groot, J., Verh. K. Ned. Akad. Wet.59 (1959) 14.
Qiu, B. S., Cho, C. H., and Ogle, C. W., Agents Action33 (1991) 367.
Masuda, M., Takeda, H., and Shibuya, T., Nippon Yakurigaku Zasshi101 (1993) 117.
Clement, H. W., Shafer, F., Ruwe, C., Gemsa, D., and Wesemann, W., Brain Res.6/4 (1993) 117.
Krowicki, Z. K., and Hornby, P. J., J. Pharmac. expl. Ther.265 (1993) 468.
Inoue, T., Koyama, T., and Yamashita, I., Pharmac. biochem. Behav.44 (1993) 371.
Davis, M., A. Rev. Neurosci.15 (1992) 353.
Morrow, N. S., Grijalva, C. V., Geiselman, P. J., and Novin, D., Physiol. Behav.53 (1993) 1043.
Carboni, E., Acquas, E., Frau, R., and Chiare, G. D., Eur. J. Pharmac.164 (1989) 515.
Galvin, G. B., Big. Dis. Sci.36 (1991) 1670.
Ogle, C. W., Qiu, B. S., and Cho, C. H., Expl clin. Gastroent.2 (1992) 41.
Yoneda, M., and Taché, Y., Neurosci. Lett.161 (1993) 199.
Cho, C. H., Qiu, B. S., Luk, C. T., and Ogle, C. W., Digestion53 (1992) 79.
Priestman, T. J., Roberts, J. T., Lucraft, H., Collis, C. H., Adams, M., Upadhyaya, B. K., and Priestman, S., Clin. Oncol.2 (1990) 71.
Jones, B. J., Costall, B., Domeney, A. M., Kelly, M. E., Naylor, R. J., Oakley, N. R., and Tyers, M. B., Br. J. Pharmac.93 (1988) 985.
Ogle, C. W., and Lau, H. K., Eur. J. Pharmac.55 (1979) 411.
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Ogle, C.W., Hui, S.C.G. The influence of peripheral or central administration of ondansetron on stress-induced gastric ulceration in rats. Experientia 51, 786–789 (1995). https://doi.org/10.1007/BF01922431
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DOI: https://doi.org/10.1007/BF01922431