Abstract
These studies were undertaken to investigate the effects of increasing or decreasing IGF-1 levels on aspects of immune function in rats. Female dwarf rats were treated with recombinant human IGF-1 or with a potent sheep anti-IGF-serum. Body weight, thymus weight and spleen weight increased with IGF-1 treatment (p<0.001), while there was no effect of anti-IGF-1 treatment when compared with the appropriate normal sheep serum (NSS) treated controls. IGF-1 treatment significantly decreased WBC and RBC counts, but increased the ratio of CD4+:CD8+ T-cells. Anti-IGF-1 serum had no effect on these parameters compared with NSS. However anti-IGF-1 was associated with increased T-cell numbers, decreased natural killer cells, and enhancement of the animals' ability to produce specific IgG in response to injection of keyhole limpet haemocyanin (KLH). These results indicate that IGF-1 may suppress immune function although increasing the size of immune organs such as spleen.
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These studies were part of an M.Sc. at the University of Waikato, Hamilton, New Zealand.
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Schurmann, A., Spencer, G.S.G., Berry, C.J. et al. Evidence for suppression of immune function by insulin-like growth factor-1 in dwarf rats in vivo. Experientia 52, 55–59 (1996). https://doi.org/10.1007/BF01922416
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DOI: https://doi.org/10.1007/BF01922416