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Growth hormone alters lymphocyte sub-populations and antibody production in dwarf rats in vivo

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Abstract

Female dwarf rats at different ages were treated with recombinant porcine GH or with a potent sheep anti-rat GH serum. Body weight and spleen weight increased with GH and decreased with anti-GH treatment (p<0.001). Neither GH nor anti-GH treatment resulted in a change in circulating WBCs, but GH decreased, while anti-GH increased, RBC counts (p<0.001). Similarly, GH treatment tended to decrease the ratio of CD4+:CD8+ T-cells while anti-GH increased (p<0.05) the ratio. Anti-GH treatment also enhanced the animals' ability to produce specific IgG in response to KLH injection. These results indicate that GH may have a physiological role in suppressing humoral immune function but may enhance cell-mediated immunity.

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  1. Ruakura Agricultural Centre, Private Bag 3123, Hamilton, New Zealand

    A. Schurmann, G. S. G. Spencer & C. J. Berry

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  1. A. Schurmann
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  2. G. S. G. Spencer
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  3. C. J. Berry
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Schurmann, A., Spencer, G.S.G. & Berry, C.J. Growth hormone alters lymphocyte sub-populations and antibody production in dwarf rats in vivo. Experientia 51, 780–785 (1995). https://doi.org/10.1007/BF01922430

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  • DOI: https://doi.org/10.1007/BF01922430

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