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Candletoxins A and B, 2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, from the irritant latex of Euphorbia poisonii Pax

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Summary

2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, known as candletoxins A and B, were isolated from the irritant latex of Euphorbia poisonii Pax. Compound A was identified as 12-deoxy-phorbol-13-O-phenylacetate-16-O-α-methyl-butyrate-20-acetate, and compound B was the C-20 desacetyl analogue.

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References

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Authors and Affiliations

  1. Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, England

    R. J. Schmidt & F. J. Evans

Authors
  1. R. J. Schmidt
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  2. F. J. Evans
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Additional information

Acknowledgments. F. J. E. is grateful to the Central Research Fund of the University of London for a travel grant to visit West Africa, and R.J.S. is indebted to the Science Research Council for a research studentship.

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Schmidt, R.J., Evans, F.J. Candletoxins A and B, 2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, from the irritant latex of Euphorbia poisonii Pax. Experientia 33, 1197–1198 (1977). https://doi.org/10.1007/BF01922325

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  • DOI: https://doi.org/10.1007/BF01922325

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