Summary
The trichomonacidal efficacy of metronidazole, tinidazole, nimorazole and ornidazole was studied in mice infected s.c., or for comparison purposes intravaginally. In both test systems, the drugs revealed nearly the same order of efficacy, whereby the compounds showed a marked decrease of activity when analyzed in s.c. infected mice.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. G. Meingassner, A. Georgopoulos and M. Patoschka, Tropenmed. Parasit.26, 395 (1975).
W. A. Müller and C. Gottschalk, Angew. Parasit.11, 170 (1970).
A. Georgopoulos, Mykosen, in press.
I. de Carneri, A. Cantone, A. Emanueli, P. N. Giraldi, W. Logemann, L. Longo, G. Meinardi, G. Monti, G. Nannini, G. Tosolini and G. Vita, Progr. Antimicrob. Anticanc. Chemother.I, 149 (1970).
J. G. Meingassner and H. Mieth, Arzneimittel-Forsch. (Drug Res.)27, 638 (1977).
Dosage specification as given by the manufacturers.
Author information
Authors and Affiliations
Additional information
I am grateful to Dr H. Mieth for helpful discussions and for his criticism of the manuscript and Miss B. Ruschizka and Mr. L. Wassermann for technical assistance.
Rights and permissions
About this article
Cite this article
Meingassner, J.G. Comparative studies on the trichomonacidal activity of 5-nitroimidazole-derivatives in mice infected s.c. or intravaginally with T. vaginalis. Experientia 33, 1160–1161 (1977). https://doi.org/10.1007/BF01922302
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01922302