Skip to main content
SpringerLink
Log in

Age-dependent change in the ability of protein synthesis, by rat liver microsomes-significance of 2 associated factors

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

An activator and an inhibitor of polypeptide synthesis were isolated from microsomes of rat liver. The young rat contained a higher level of the activator but a lower level of the inhibitor than the aged rat. The significantly higher ratio of the specific activity of the activator to inhibitor in the young microsomes helps explain the higher capacity for protein synthesis of these microsomes as compared to the microsomes of the aged animal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. W. I. P. Mainwaring, Biochem. J.113, 869 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. M. N. D. Goswami and M. Kermel, 10th Meet. Fed. Eur. Biochem. Soc., Paris 1975, abstr. No. 528.

  3. K. Moldave and L. Skogerson, Meth. Enzym.12, 478 (1967).

    Article  Google Scholar 

  4. E. B. Keller and P. C. Zamecnik, J. biol. Chem.221, 45 (1956).

    Article  CAS  PubMed  Google Scholar 

  5. A. J. Shatkin, in: Fundamental Technique in Virology, p. 231. Ed. K. Habel and N. P. Saltzman. Acad. Press Inc. N.Y. 1969.

    Google Scholar 

  6. O. H. Lowry, N. J. Rosebrough, A. L., Farr and R. J. Randall, J. biol. Chem.,193, 265 (1951).

    Article  CAS  PubMed  Google Scholar 

  7. M. N. D. Goswami and M. Kermel, C. r. Acad. Sci. Paris280, 2345 (1975).

    CAS  Google Scholar 

  8. M. B. Hoagland, O. A. Scornik and L. C. Pfefferkorn, Proc. Nat. Acad. Sci. USA51, 1184 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. M. N. D. Goswami, 10th Int. Cong. Biochem. Hamburg 1976, abstr. No. 03-6-108, p. 125.

  10. M. N. D. Goswami, 172nd Am. Chem. Soc. Meet. San Francisco 1976, abstr. No. 211.

  11. M. N. D. Goswami and M. Kermel, c. r. Acad. Sci. Paris282, 77 (1976).

    CAS  Google Scholar 

  12. R. L. Miller and R. Schweet, Archs Biochem. Biophys.25, 632 (1968).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut Gustave-Roussy, Laboratoire de Physio-pathologie (C. N. R. S. Res. G. R. no 8), F-94800, Villejuit, France

    M. N. D. Goswami

Authors
  1. M. N. D. Goswami
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The author thanks Mrs. M. Guillier for her technical help in this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goswami, M.N.D. Age-dependent change in the ability of protein synthesis, by rat liver microsomes-significance of 2 associated factors. Experientia 33, 469–470 (1977). https://doi.org/10.1007/BF01922215

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01922215

Keywords

Search

Navigation