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Synthesis and Posttranslational Modifications of Proteins

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Molecular Biology

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 8248))

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Abstract

Protein synthesis (translation) is a process in which more than one hundred macromolecules work together in a coordinated way. Translation is carried out on ribosomes by tRNA, and on the mRNA template sequence (ch. 3.3). Messenger RNA sequence is translated to the protein sequence. Translation starts from the 5’ end of the mRNA and follows to 3’ end strictly in accordance with ternary code (three nucleotides for one amino acid), that is according to the reading frame. Even a small change in the mRNA sequence can lead to the production of completely different protein, for example when amino acid codon is changed to a stop codon produced protein will be shorter. Frameshift can also occur.

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References

  1. Berg, J.M., Tymoczko, J.L., Stryer, L.: Protein Synthesis. In: Biochemistry, 5th edn. W.H. Freeman, New York (2002)

    Google Scholar 

  2. Clancy, S., Brown, W.: Translation: DNA to mRNA to protein. Nature Education 1(1) (2008), http://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393

  3. Cooper, G.M.: Protein Degradation. In: The Cell: A Molecular Approach, 2nd edn. Sinauer Associates, Sunderland, MA (2000), http://www.ncbi.nlm.nih.gov/books/NBK9957

  4. King, M.W.: Translation of Proteins. In: themedicalbiochemistrypage.org, LLC (1996-2012), http://themedicalbiochemistrypage.org/protein-synthesis.php

  5. King, M.W.: Protein Modifications. In: themedicalbiochemistrypage.org, LLC (1996-2012), http://themedicalbiochemistrypage.org/protein-modifications.php

  6. Lodish, H., Berk, A., Zipursky, S.L., et al.: Protein Sorting: Organelle Biogenesis and Protein Secretion. In: Molecular Cell Biology, 4th edn. W.H. Freeman, New York (2000)

    Google Scholar 

  7. Makalowska, I., Lin, C.F., Makalowski, W.: Overlapping genes in vertebrate genomes. Comput. Biol. Chem. 29, 1–12 (2005)

    Article  MATH  Google Scholar 

  8. Mazumder, B., Seshadri, V., Fox, P.L.: Translational control by the 3’-UTR: the ends specify the means. Trends Biochem. Sci. 28, 91–98 (2003)

    Article  Google Scholar 

  9. Muratani, M., Tansey, W.P.: How the ubiquitin-proteasome system controls transcription. Nat. Rev. Mol. Cell. Biol. 4, 192–201 (2003)

    Article  Google Scholar 

  10. Poon, I.K., Jans, D.A.: Regulation of nuclear transport: central role in development and transformation? Traffic 6, 173–186 (2005)

    Article  Google Scholar 

  11. Rape, M., Jentsch, S.: Productive RUPture: activation of transcription factors by proteasomal processing. Biochim. Biophys. Acta 1695, 209–213 (2004)

    Article  Google Scholar 

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Widłak, W. (2013). Synthesis and Posttranslational Modifications of Proteins. In: Widłak, W. (eds) Molecular Biology. Lecture Notes in Computer Science(), vol 8248. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45361-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-45361-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45360-1

  • Online ISBN: 978-3-642-45361-8

  • eBook Packages: Computer ScienceComputer Science (R0)

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