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Phosphonacetyl-L-aspartate: An aspartate transcarbamylase inhibitor causing larval death and rudimentary wing phenocopies in Drosophila melanogaster

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Summary

Phosphonacetyl-L-aspartate, an inhibitor and transition state analogue of aspartate transcarbamylase, has been found to cause rudimentary wing phenocopies and larval death in Drosophila melanogaster. We believe this compound may prove useful as a selection agent for regulatory mutations at the rudimentary locus.

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Authors and Affiliations

  1. Department of Genetics, University of California, 94720, Berkeley, California, USA

    Bettie J. Holaday & J. W. Fristrom

Authors
  1. Bettie J. Holaday
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  2. J. W. Fristrom
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Additional information

Acknowledgments. We are grateful to A. Thurmond for technical assistance. This work was supported in part by a grant from the National Science Foundation (PCM) 75-22802).

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Holaday, B.J., Fristrom, J.W. Phosphonacetyl-L-aspartate: An aspartate transcarbamylase inhibitor causing larval death and rudimentary wing phenocopies in Drosophila melanogaster. Experientia 33, 428–430 (1977). https://doi.org/10.1007/BF01922192

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