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The synthesis of total and specific glycosaminoglycans during development of experimental liver cirrhosis

  • Specialia Chimica, Biochimica
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Summary

During hepatic fibrogenesis induced by long-term administration of thioacetamide, the synthsis of chondroitin 4,6-sulfate and hyaluronic acid was strongly enhanced; the formation of heparan sulfate comprising at least 70% of total liver GAG synthesis and of a keratan-sulfate-like fraction was stimulated 1.7fold. Formation of dermatan-sulfate in liver could not be detected.

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Authors and Affiliations

  1. Department of Clinical Chemistry of the Medical Faculty of the RWTH, Goethestrasse 27-29, D-51, Aachen, Federal Republic of Germany

    A. M. Gressner, Hildegard Pazen & H. Greiling

Authors
  1. A. M. Gressner
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  2. Hildegard Pazen
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  3. H. Greiling
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Additional information

We are grateful to Prof. W. Kühnel, Department of Anatomy, and to Prof. R. Lindenfelser, Department of Pathology, RWTH Aachen, for critical examination of the histology.

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Gressner, A.M., Pazen, H. & Greiling, H. The synthesis of total and specific glycosaminoglycans during development of experimental liver cirrhosis. Experientia 33, 1290–1292 (1977). https://doi.org/10.1007/BF01920139

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  • DOI: https://doi.org/10.1007/BF01920139

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