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N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1)

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Handbook of Glycosyltransferases and Related Genes

Abstract

Heparan sulfate (HS) is expressed on virtually all cells of vertebrate and invertebrate developing embryos and adult tissues as part of HS proteoglycans (HSPGs). The HSPGs perlecan, agrin, and collagen XVIII are found in basement membranes, while HSPGs belonging to the syndecan and glypican families are cell surface bound. Many growth factors, morphogens, chemokines, and cytokines bind to HS, and HSPGs are thought to act as coreceptors for these molecules. In addition, HSPGs play important roles in cell-matrix adhesion, lipoprotein metabolism, virus and parasite infection, and protease/protease inhibitor binding and activity regulation (Kjellén and Lindahl 1991). This makes regulated HS biosynthesis essential for unimpaired embryonic development as well as for adult homeostasis.

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Authors and Affiliations

  1. Institute for Physiological Chemistry and Pathobiochemistry, University Hospital Münster, Westfälische Wilhelms-Universität Münster, Waldeyerstr. 15, D-48149, Münster, Germany

    Dr. Kay Grobe

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  1. Dr. Kay Grobe
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Correspondence to Kay Grobe .

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Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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© 2014 Springer Japan

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Grobe, K. (2014). N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_54

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