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Comparison of X-prolyl dipeptidyl-aminopeptidase activity in human cerebrospinal fluid with that in serum

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Summary

X-Prolyl dipeptidyl-aminopeptidase activities in cerebrospinal fluid and serum from the same patients without neurological diseases, undergoing surgery under lumbar anesthesia, were assayed fluorometrically with a newly synthesized fluorogenic substrate, 7-glycylproline-4-methylcoumarinamide; the values were 129.1±19.5 nmoles/min/1 and 54.17±3.11 μmoles/min/1 (mean±SEM, n=23), respectively, and there was no correlation between both activities (r=0.0894).

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Authors and Affiliations

  1. Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, 227, Yokohama, (Japan)

    T. Kato, K. Iwase, T. Nagatsu, S. Sakakibara & K. Fujita

  2. Peptide Institute, Protein Research Foundation, 562, Minoh, Osaka, (Japan)

    T. Kato, K. Iwase, T. Nagatsu, S. Sakakibara & K. Fujita

  3. School of Medicine, Fujita-Gakuen University, 470-11, Toyoake, Aichi, (Japan)

    T. Kato, K. Iwase, T. Nagatsu, S. Sakakibara & K. Fujita

Authors
  1. T. Kato
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  2. K. Iwase
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  3. T. Nagatsu
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  4. S. Sakakibara
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  5. K. Fujita
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Kato, T., Iwase, K., Nagatsu, T. et al. Comparison of X-prolyl dipeptidyl-aminopeptidase activity in human cerebrospinal fluid with that in serum. Experientia 35, 20–21 (1979). https://doi.org/10.1007/BF01917849

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