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Induction of electrical excitability in crustacean muscle by 4-cyclopentene-1,3-dione

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Summary

4-Cyclopentene-1,3-dione induces electrical activity in inexcitable crustacean muscle. This effect is blocked by previous treatment with p-chloromercuribenzoic acid. These results suggest that crustacean muscle becomes excitable when certain-CH2-SH side chains are converted to thioethers having carbonyl groups.

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Abbreviations

NEM:

N-ethylmaleimide

4-CPD:

4-cyclopentene-1,3-dione

PCMB:

p-chloromercuribenzoic acid

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Author information

Authors and Affiliations

  1. Laboratory of Neurobiology and Department of Pharmacology, University of Puerto Rico, Medical Sciences Campus, 00936, San Juan, Puerto Rico, USA

    C. Zuazaga de Ortiz & J. del Castillo

Authors
  1. C. Zuazaga de Ortiz
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  2. J. del Castillo
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Additional information

Acknowledgments. This work was supported by USPHS Nos NS-07464, NS-14938 and GM-05784. Contribution No. 80 of the Laboratory of Neurobiology.

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Zuazaga de Ortiz, C., del Castillo, J. Induction of electrical excitability in crustacean muscle by 4-cyclopentene-1,3-dione. Experientia 34, 1033–1034 (1978). https://doi.org/10.1007/BF01915330

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